Tissue expression of SALL3 - Summary - The Human Protein Atlas

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SALL3

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SALL3
Gene description	Spalt-like transcription factor 3
Protein class	Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex, prostate)
GTEx:	Tissue enhanced (vagina)
FANTOM5:	Tissue enhanced (caudate, hippocampus)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA016656
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex, prostate)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (vagina)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (caudate, hippocampus)

GENE INFORMATION
Gene name	SALL3 (HGNC Symbol)
Synonyms	ZNF796
Description	Spalt-like transcription factor 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a sal-like C2H2-type zinc-finger protein, and belongs to a family of evolutionarily conserved genes found in species as diverse as Drosophila, C. elegans, and vertebrates. Mutations in some of these genes are associated with congenital disorders in human, suggesting their importance in embryonic development. This protein binds to DNA methyltransferase 3 alpha (DNMT3A), and reduces DNMT3A-mediated CpG island methylation. It is suggested that silencing of this gene, resulting in acceleration of DNA methylation, may have a role in oncogenesis. [provided by RefSeq, Oct 2011]
Chromosome	18
Cytoband	q23
Chromosome location (bp)	78980275 - 79002677
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000256463 (version 83.38)
Entrez gene	27164
UniProt	Q9BXA9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BXA9
Antibodypedia	SALL3 antibodies

PROTEIN BROWSER

SALL3-001	SALL3-002	SALL3-003	SALL3-006	SALL3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SALL3-001 ENSP00000441823 ENST00000537592	Q9BXA9 [Direct mapping] Sal-like protein 3 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0021891 [olfactory bulb interneuron development] GO:0022008 [neurogenesis] GO:0035136 [forelimb morphogenesis] GO:0035137 [hindlimb morphogenesis] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045879 [negative regulation of smoothened signaling pathway] GO:0046872 [metal ion binding] Show all	1300 aa 135.3 kDa	No	0
SALL3-002 ENSP00000458360 ENST00000575389	Q9BXA9 [Direct mapping] Sal-like protein 3 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0022008 [neurogenesis] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0046872 [metal ion binding] Show all	1228 aa 127.3 kDa	No	0
SALL3-003 ENSP00000461451 ENST00000573324	I3L3L8 [Direct mapping] Sal-like protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	150 aa 15.2 kDa	No	0
SALL3-006 ENSP00000439975 ENST00000536229	Q9BXA9 [Direct mapping] Sal-like protein 3 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0022008 [neurogenesis] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0046872 [metal ion binding] Show all	1095 aa 113.2 kDa	No	0
SALL3-201 ENSP00000481352 ENST00000616649	A0A087WXW6 [Direct mapping] Sal-like protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	960 aa 101.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.