Cell atlas - THTPA - The Human Protein Atlas

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THTPA

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	THTPA
Gene description	Thiamine triphosphatase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the nucleoli.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (uncertain)
Additional location	In addition localized to the Nucleoli (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA028876
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the nucleoli.

Main location

Nucleus (uncertain)

Additional location

Nucleoli (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA028876	A-431	Nucleus
	HPA028876	U-2 OS	Nucleus
	HPA028876	U-251 MG	Nucleus
	HPA028876	U-251 MG	Nucleoli

GENE INFORMATION
Gene name	THTPA (HGNC Symbol)
Synonyms	THTPASE
Description	Thiamine triphosphatase (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme which catalyzes the biosynthesis of thiamine disphophate (vitamin B1) by hydrolysis of thiamine triphosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Chromosome	14
Cytoband	q11.2
Chromosome location (bp)	23555988 - 23560271
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000259431 (version 83.38)
Entrez gene	79178
UniProt	Q9BU02 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BU02
Antibodypedia	THTPA antibodies

PROTEIN BROWSER

THTPA-001	THTPA-002	THTPA-003	THTPA-005	THTPA-007	THTPA-008	THTPA-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
THTPA-001 ENSP00000288014 ENST00000288014	Q9BU02 [Direct mapping] Thiamine-triphosphatase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0005829 [cytosol] GO:0006091 [generation of precursor metabolites and energy] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006772 [thiamine metabolic process] GO:0016311 [dephosphorylation] GO:0016787 [hydrolase activity] GO:0042357 [thiamine diphosphate metabolic process] GO:0042723 [thiamine-containing compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0050333 [thiamin-triphosphatase activity] Show all	230 aa 25.6 kDa	No	0
THTPA-002 ENSP00000384580 ENST00000404535	Q9BU02 [Direct mapping] Thiamine-triphosphatase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0005829 [cytosol] GO:0006091 [generation of precursor metabolites and energy] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006772 [thiamine metabolic process] GO:0016311 [dephosphorylation] GO:0016787 [hydrolase activity] GO:0042357 [thiamine diphosphate metabolic process] GO:0042723 [thiamine-containing compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0050333 [thiamin-triphosphatase activity] Show all	230 aa 25.6 kDa	No	0
THTPA-003 ENSP00000450459 ENST00000554789	Q9BU02 [Direct mapping] Thiamine-triphosphatase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0005829 [cytosol] GO:0006091 [generation of precursor metabolites and energy] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006772 [thiamine metabolic process] GO:0016311 [dephosphorylation] GO:0016787 [hydrolase activity] GO:0042357 [thiamine diphosphate metabolic process] GO:0042723 [thiamine-containing compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0050333 [thiamin-triphosphatase activity] Show all	105 aa 12 kDa	No	0
THTPA-005 ENSP00000452164 ENST00000556545	H0YJU8 [Direct mapping] Thiamine-triphosphatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		60 aa 6.7 kDa	No	0
THTPA-007 ENSP00000451835 ENST00000556015	Q9BU02 [Direct mapping] Thiamine-triphosphatase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0005829 [cytosol] GO:0006091 [generation of precursor metabolites and energy] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006772 [thiamine metabolic process] GO:0016311 [dephosphorylation] GO:0016787 [hydrolase activity] GO:0042357 [thiamine diphosphate metabolic process] GO:0042723 [thiamine-containing compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0050333 [thiamin-triphosphatase activity] Show all	105 aa 12 kDa	No	0
THTPA-008 ENSP00000452465 ENST00000554970	G3V5Q5 [Direct mapping] Thiamine-triphosphatase Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		140 aa 16 kDa	No	0
THTPA-009 ENSP00000452281 ENST00000557630	G3V5B9 [Direct mapping] Thiamine-triphosphatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		123 aa 13.5 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.