Cell atlas - SCRT1 - The Human Protein Atlas

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SCRT1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SCRT1
Gene description	Scratch family zinc finger 1
Protein class	Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear bodies.
RNA cell category	Group enriched (SCLC-21H, SH-SY5Y)
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear bodies (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA045265
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (SCLC-21H, SH-SY5Y) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear bodies.

Main location

Nuclear bodies (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA045265	SH-SY5Y	Nuclear bodies

GENE INFORMATION
Gene name	SCRT1 (HGNC Symbol)
Synonyms	DKFZp547F072, ZNF898
Description	Scratch family zinc finger 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a C2H2-type zinc finger transcriptional repressor that binds to E-box motifs. The encoded protein may promote neural differention and may be involved in cancers with neuroendocrine features. [provided by RefSeq, Jul 2013]
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	144330565 - 144336281
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000261678 (version 83.38)
Entrez gene	83482
UniProt	Q9BWW7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BWW7
Antibodypedia	SCRT1 antibodies

PROTEIN BROWSER

SCRT1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SCRT1-001 ENSP00000455711 ENST00000569446	Q9BWW7 [Direct mapping] Transcriptional repressor scratch 1 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:2001222 [regulation of neuron migration] Show all	348 aa 35.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.