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Gene name

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Chromosome

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In atlas

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Reliability

Reliability

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Validation

Method

Validation

Method

Validation

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Searches

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Expression

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Cell line

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Tissue

Detectable

Cell line

Detectable

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Antibodies

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RPL17
  • premium

    TISSUE

  • premium

    CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

Ribosomal protein L17

Protein class

Plasma proteins, Predicted intracellular proteins, Ribosomal proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA043724
HPA046385

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignant tissues displayed weak to moderate cytoplasmic immunoreactivity. Renal cancers were generally weakly stained or negative.

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant tissues showed weak to moderate cytoplasmic and occasional nucleolar staining. Several cases of hepatocellular carcinomas along with occasional cases of stomach, colorectal and pancreatic cancers displayed strong positivity. Several cases of malignant gliomas, carcinoids and lymphomas were negative.

GENE INFORMATION

Gene name

RPL17 (HGNC Symbol)

Synonyms

L17, rpL23

Description

Ribosomal protein L17 (HGNC Symbol)

Entrez gene summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL23 because the encoded protein shares amino acid identity with ribosomal protein L23 from Halobacterium marismortui; however, its official symbol is RPL17. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream C18orf32 (chromosome 18 open reading frame 32) gene. [provided by RefSeq, Dec 2010]

Chromosome

18

Cytoband

q21.1

Chromosome location (bp)

49488453 - 49492523

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000265681 (version 83.38)

Entrez gene

6139

UniProt

P18621 (UniProt - Evidence at protein level)

neXtProt

NX_P18621

Antibodypedia

RPL17 antibodies

PROTEIN BROWSER

«
RPL17-001
RPL17-002
RPL17-003
RPL17-008
RPL17-010
RPL17-015
RPL17-016
RPL17-017
RPL17-018
RPL17-019
RPL17-022
RPL17-023
RPL17-024
RPL17-025
RPL17-026
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RPL17-001
ENSP00000462385
ENST00000580261
P18621 [Direct mapping]
60S ribosomal protein L17
A0A024R261 [Target identity:100%; Query identity:100%]
HCG24487, isoform CRA_c
Show all
Ribosomal proteins
Predicted intracellular proteins
Plasma proteins
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0002181 [cytoplasmic translation]
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0010467 [gene expression]
GO:0015934 [large ribosomal subunit]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0022625 [cytosolic large ribosomal subunit]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
Show all
184 aa
21.4 kDa
No 0
RPL17-002
ENSP00000462944
ENST00000581373
P18621 [Direct mapping]
60S ribosomal protein L17
Show all
Ribosomal proteins
Predicted intracellular proteins
Plasma proteins
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0002181 [cytoplasmic translation]
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0010467 [gene expression]
GO:0015934 [large ribosomal subunit]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0022625 [cytosolic large ribosomal subunit]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
Show all
146 aa
17.1 kDa
No 0
RPL17-003
ENSP00000463842
ENST00000579408
P18621 [Direct mapping]
60S ribosomal protein L17
A0A024R261 [Target identity:100%; Query identity:100%]
HCG24487, isoform CRA_c
Show all
Ribosomal proteins
Predicted intracellular proteins
Plasma proteins
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0002181 [cytoplasmic translation]
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0010467 [gene expression]
GO:0015934 [large ribosomal subunit]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0022625 [cytosolic large ribosomal subunit]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
Show all
184 aa
21.4 kDa
No 0
RPL17-008
ENSP00000464586
ENST00000583036
J3QS96 [Direct mapping]
60S ribosomal protein L17
Show all
Predicted intracellular proteins
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0015934 [large ribosomal subunit]
Show all
138 aa
16 kDa
No 0
RPL17-010
ENSP00000462508
ENST00000578528
J3KSJ0 [Direct mapping]
60S ribosomal protein L17
Show all
Predicted intracellular proteins
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0015934 [large ribosomal subunit]
Show all
56 aa
6.5 kDa
No 0
RPL17-015
ENSP00000463490
ENST00000580210
J3QLC8 [Direct mapping]
60S ribosomal protein L17
Show all
Predicted intracellular proteins
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0015934 [large ribosomal subunit]
Show all
174 aa
20.2 kDa
No 0
RPL17-016
ENSP00000462203
ENST00000583637
J3KRX5 [Direct mapping]
60S ribosomal protein L17
Show all
Predicted intracellular proteins
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0015934 [large ribosomal subunit]
Show all
174 aa
20.2 kDa
No 0
RPL17-017
ENSP00000463885
ENST00000578532
J3QQT2 [Direct mapping]
60S ribosomal protein L17
Show all
Predicted intracellular proteins
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0015934 [large ribosomal subunit]
Show all
171 aa
19.8 kDa
No 0
RPL17-018
ENSP00000462023
ENST00000579248
P18621 [Direct mapping]
60S ribosomal protein L17
A0A024R261 [Target identity:100%; Query identity:100%]
HCG24487, isoform CRA_c
Show all
Ribosomal proteins
Predicted intracellular proteins
Plasma proteins
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0002181 [cytoplasmic translation]
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0010467 [gene expression]
GO:0015934 [large ribosomal subunit]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0022625 [cytosolic large ribosomal subunit]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
Show all
184 aa
21.4 kDa
No 0
RPL17-019
ENSP00000461910
ENST00000580387
J3KRB3 [Direct mapping]
60S ribosomal protein L17
Show all
Predicted intracellular proteins
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0015934 [large ribosomal subunit]
Show all
129 aa
14.9 kDa
No 0
RPL17-022
ENSP00000481145
ENST00000617346
A0A087WXM6 [Direct mapping]
60S ribosomal protein L17
Show all
Predicted intracellular proteins
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0015934 [large ribosomal subunit]
Show all
169 aa
19.6 kDa
No 0
RPL17-023
ENSP00000482577
ENST00000618619
P18621 [Direct mapping]
60S ribosomal protein L17
A0A024R261 [Target identity:100%; Query identity:100%]
HCG24487, isoform CRA_c
Show all
Ribosomal proteins
Predicted intracellular proteins
Plasma proteins
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0002181 [cytoplasmic translation]
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0010467 [gene expression]
GO:0015934 [large ribosomal subunit]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0022625 [cytosolic large ribosomal subunit]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
Show all
184 aa
21.4 kDa
No 0
RPL17-024
ENSP00000480215
ENST00000615760
A0A087WWH0 [Direct mapping]
60S ribosomal protein L17
Show all
Predicted intracellular proteins
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0015934 [large ribosomal subunit]
Show all
132 aa
15.3 kDa
No 0
RPL17-025
ENSP00000481587
ENST00000615479
A0A087WY81 [Direct mapping]
60S ribosomal protein L17
Show all
Predicted intracellular proteins
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0015934 [large ribosomal subunit]
Show all
98 aa
11.4 kDa
No 0
RPL17-026
ENSP00000480555
ENST00000618613
P18621 [Direct mapping]
60S ribosomal protein L17
A0A024R261 [Target identity:100%; Query identity:100%]
HCG24487, isoform CRA_c
Show all
Ribosomal proteins
Predicted intracellular proteins
Plasma proteins
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0002181 [cytoplasmic translation]
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0010467 [gene expression]
GO:0015934 [large ribosomal subunit]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0022625 [cytosolic large ribosomal subunit]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
Show all
184 aa
21.4 kDa
No 0

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