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DOC2B

CANCER ATLAS

Gene description

 Double C2-like domains, beta

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA043168

GENE INFORMATION

Gene name

 DOC2B (HGNC Symbol)

Synonyms

 DOC2BL

Description

 Double C2-like domains, beta (HGNC Symbol)

Entrez gene summary

 There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2B is expressed ubiquitously and is suggested to be involved in Ca(2+)-dependent intracellular vesicle trafficking in various types of cells. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 p13.3

Chromosome location (bp)

 142789 - 181636

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000272636 (version 83.38)

Entrez gene

 8447

UniProt

neXtProt

Antibodypedia

 DOC2B antibodies

PROTEIN BROWSER
DOC2B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DOC2B-001
ENSP00000482950
ENST00000613549
A0A087WZX8 [Direct mapping]
Double C2-like domain-containing protein
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0008104 [protein localization]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0032024 [positive regulation of insulin secretion]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 412 aa
45.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.