Cell atlas - DOC2B - The Human Protein Atlas

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DOC2B

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	DOC2B
Gene description	Double C2-like domains, beta
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enriched (SH-SY5Y)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (SH-SY5Y) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	DOC2B (HGNC Symbol)
Synonyms	DOC2BL
Description	Double C2-like domains, beta (HGNC Symbol)
Entrez gene summary	There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2B is expressed ubiquitously and is suggested to be involved in Ca(2+)-dependent intracellular vesicle trafficking in various types of cells. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p13.3
Chromosome location (bp)	142789 - 181636
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000272636 (version 83.38)
Entrez gene	8447
UniProt
neXtProt
Antibodypedia	DOC2B antibodies

PROTEIN BROWSER

DOC2B-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DOC2B-001 ENSP00000482950 ENST00000613549	A0A087WZX8 [Direct mapping] Double C2-like domain-containing protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0008104 [protein localization] GO:0017158 [regulation of calcium ion-dependent exocytosis] GO:0019905 [syntaxin binding] GO:0032024 [positive regulation of insulin secretion] GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter] Show all	412 aa 45.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.