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ADRA2B

GENERAL INFORMATION

Gene name

 ADRA2B

Gene description

 Adrenoceptor alpha 2B

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
FANTOM5:Mixed

Protein evidence

 Evidence at transcript level

Protein expression

 Cytoplasmic expression in Purkinje cells in cerebellum.

DATA RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA066029
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 ADRA2B (HGNC Symbol)

Synonyms

 ADRA2L1, ADRA2RL1, ADRARL1

Description

 Adrenoceptor alpha 2B (HGNC Symbol)

Entrez gene summary

 This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014]

Chromosome

 2

Cytoband

 q11.2

Chromosome location (bp)

 96112875 - 96116245

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000274286 (version 83.38)

Entrez gene

 151

UniProt

neXtProt

Antibodypedia

 ADRA2B antibodies

PROTEIN BROWSER
ADRA2B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADRA2B-001
ENSP00000480573
ENST00000620793
A2RUS0 [Direct mapping]
Adrenergic, alpha-2B-, receptor; Alpha-2B adrenergic receptor; HCG37297
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
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GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0001525 [angiogenesis]
GO:0003056 [regulation of vascular smooth muscle contraction]
GO:0004930 [G-protein coupled receptor activity]
GO:0004935 [adrenergic receptor activity]
GO:0004938 [alpha2-adrenergic receptor activity]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007565 [female pregnancy]
GO:0016021 [integral component of membrane]
GO:0030168 [platelet activation]
GO:0045777 [positive regulation of blood pressure]
GO:0070474 [positive regulation of uterine smooth muscle contraction]
GO:0071875 [adrenergic receptor signaling pathway]
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 450 aa
50 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.