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Several cases of hepatocellular carcinomas displayed moderate to strong cytoplasmic positivity. Several cases of carcinoid showed weak cytoplasmic and nuclear staining while head and neck cancers, melanomas, testis and skin cancers exhibited weak nuclear immunoreactivity. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
ZNF280B (HGNC Symbol)
Synonyms
5'OY11.1, SUHW2, ZNF279, ZNF632
Description
Zinc finger protein 280B (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding. [provided by RefSeq, Jan 2015]
