Cell atlas - ZNF280B - The Human Protein Atlas

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ZNF280B

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ZNF280B
Gene description	Zinc finger protein 280B
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Cell line enhanced (K-562, U-2 OS)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA059519
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (K-562, U-2 OS) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA059519	HEK 293	Nucleoplasm
	HPA059519	Hep G2	Nucleoplasm
	HPA059519	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	ZNF280B (HGNC Symbol)
Synonyms	5'OY11.1, SUHW2, ZNF279, ZNF632
Description	Zinc finger protein 280B (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding. [provided by RefSeq, Jan 2015]
Chromosome	22
Cytoband	q11.22
Chromosome location (bp)	22484421 - 22509154
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000275004 (version 83.38)
Entrez gene	140883
UniProt	Q86YH2 (UniProt - Evidence at protein level)
neXtProt	NX_Q86YH2
Antibodypedia	ZNF280B antibodies

PROTEIN BROWSER

ZNF280B-001	ZNF280B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZNF280B-001 ENSP00000485750 ENST00000626650	A0A0D9SEJ8 [Direct mapping] Suppressor of hairy wing homolog 2 (Drosophila), isoform CRA_b; Zinc finger protein 280B Show all	Predicted intracellular proteins Show all	GO:0046872 [metal ion binding] Show all	543 aa 61.5 kDa	No	0
ZNF280B-201 ENSP00000481008 ENST00000613655	Q86YH2 [Direct mapping] Zinc finger protein 280B Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	543 aa 61.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.