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CCL18

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GENERAL INFORMATION

Gene name

 CCL18

Gene description

 Chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)

Protein class

 Cancer-related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Not detected

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CCL18 (HGNC Symbol)

Synonyms

 AMAC-1, CKb7, DC-CK1, DCCK1, MIP-4, PARC, SCYA18

Description

 Chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) (HGNC Symbol)

Entrez gene summary

 This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Sep 2014]

Chromosome

 17

Cytoband

 q12

Chromosome location (bp)

 36064280 - 36072032

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000275385 (version 83.38)

Entrez gene

 6362

UniProt

 P55774 (UniProt - Evidence at protein level)

neXtProt

 NX_P55774

Antibodypedia

 CCL18 antibodies

PROTEIN BROWSER
CCL18-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCL18-001
ENSP00000479955
ENST00000616054
P55774 [Direct mapping]
C-C motif chemokine 18 CCL18(1-68) CCL18(3-69) CCL18(4-69)
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Show all
GO:0002548 [monocyte chemotaxis]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007154 [cell communication]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008009 [chemokine activity]
GO:0009607 [response to biotic stimulus]
GO:0030593 [neutrophil chemotaxis]
GO:0043547 [positive regulation of GTPase activity]
GO:0048020 [CCR chemokine receptor binding]
GO:0048245 [eosinophil chemotaxis]
GO:0048247 [lymphocyte chemotaxis]
GO:0050729 [positive regulation of inflammatory response]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071346 [cellular response to interferon-gamma]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
Show all
 89 aa
9.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.