Tissue expression of CCL18 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CCL18
Gene description	Chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
Protein class	Cancer-related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (adipose tissue, lung, tonsil)
FANTOM5:	Tissue enhanced (lung, lymph node)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adipose tissue, lung, tonsil)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung, lymph node)

GENE INFORMATION
Gene name	CCL18 (HGNC Symbol)
Synonyms	AMAC-1, CKb7, DC-CK1, DCCK1, MIP-4, PARC, SCYA18
Description	Chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) (HGNC Symbol)
Entrez gene summary	This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Sep 2014]
Chromosome	17
Cytoband	q12
Chromosome location (bp)	36064280 - 36072032
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000275385 (version 83.38)
Entrez gene	6362
UniProt	P55774 (UniProt - Evidence at protein level)
neXtProt	NX_P55774
Antibodypedia	CCL18 antibodies

PROTEIN BROWSER

CCL18-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCL18-001 ENSP00000479955 ENST00000616054	P55774 [Direct mapping] C-C motif chemokine 18 CCL18(1-68) CCL18(3-69) CCL18(4-69) Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Show all	GO:0002548 [monocyte chemotaxis] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007154 [cell communication] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0008009 [chemokine activity] GO:0009607 [response to biotic stimulus] GO:0030593 [neutrophil chemotaxis] GO:0043547 [positive regulation of GTPase activity] GO:0048020 [CCR chemokine receptor binding] GO:0048245 [eosinophil chemotaxis] GO:0048247 [lymphocyte chemotaxis] GO:0050729 [positive regulation of inflammatory response] GO:0070098 [chemokine-mediated signaling pathway] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071346 [cellular response to interferon-gamma] GO:0071347 [cellular response to interleukin-1] GO:0071356 [cellular response to tumor necrosis factor] Show all	89 aa 9.8 kDa	Yes	0