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Colorectal, renal, gastric, pancreas and liver cancers along with few cases of testis, ovarian, cervical, urothelial cancers and carcinoids showed moderate to strong nuclear positivity. Remaining cancer tissues were generally negative.
GENE INFORMATION
Gene name
HNF1B (HGNC Symbol)
Synonyms
HNF1beta, LFB3, MODY5, TCF2, VHNF1
Description
HNF1 homeobox B (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]