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AATF

GENERAL INFORMATION

Gene name

 AATF

Gene description

 Apoptosis antagonizing transcription factor

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous granular cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Sub cellular location is contradicted by external data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA004940
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 AATF (HGNC Symbol)

Synonyms

 BFR2, CHE-1, CHE1, DED

Description

 Apoptosis antagonizing transcription factor (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q12

Chromosome location (bp)

 36948875 - 37056871

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000275700 (version 83.38)

Entrez gene

 26574

UniProt

 Q9NY61 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NY61

Antibodypedia

 AATF antibodies

PROTEIN BROWSER
AATF-001
AATF-006
AATF-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AATF-001
ENSP00000477848
ENST00000619387
Q9NY61 [Direct mapping]
Protein AATF
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005925 [focal adhesion]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007155 [cell adhesion]
GO:0007346 [regulation of mitotic cell cycle]
GO:0019904 [protein domain specific binding]
GO:0032929 [negative regulation of superoxide anion generation]
GO:0040016 [embryonic cleavage]
GO:0042254 [ribosome biogenesis]
GO:0042985 [negative regulation of amyloid precursor protein biosynthetic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043522 [leucine zipper domain binding]
GO:0044822 [poly(A) RNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048156 [tau protein binding]
GO:0097190 [apoptotic signaling pathway]
GO:2000378 [negative regulation of reactive oxygen species metabolic process]
Show all
 560 aa
63.1 kDa 		No 0
AATF-006
ENSP00000480472
ENST00000610798
A0A087WWS8 [Direct mapping]
Protein AATF
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Predicted intracellular proteins
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GO:0005634 [nucleus]
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 154 aa
17.8 kDa 		No 0
AATF-007
ENSP00000477881
ENST00000616434
A0A087WTH8 [Direct mapping]
Protein AATF
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Predicted intracellular proteins
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GO:0005634 [nucleus]
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 98 aa
11.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.