Expression of ORAI1 in cancer - Summary

CANCER ATLAS

Gene description

ORAI calcium release-activated calcium modulator 1

Protein class

Disease related genes, Potential drug targets, Predicted membrane proteins, Predicted secreted proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA016583

GENE INFORMATION
Gene name	ORAI1 (HGNC Symbol)
Synonyms	CRACM1, FLJ14466, TMEM142A
Description	ORAI calcium release-activated calcium modulator 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]
Chromosome	12
Cytoband	q24.31
Chromosome location (bp)	121626550 - 121642677
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000276045 (version 83.38)
Entrez gene	84876
UniProt	Q96D31 (UniProt - Evidence at protein level)
neXtProt	NX_Q96D31
Antibodypedia	ORAI1 antibodies

PROTEIN BROWSER

ORAI1-001	ORAI1-002	ORAI1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ORAI1-001 ENSP00000482568 ENST00000617316	A0A0B4J2E8 [Direct mapping] Calcium release-activated calcium channel protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	238 aa 26.1 kDa	Yes	3
ORAI1-002 ENSP00000477953 ENST00000611718	A0A087WTK9 [Direct mapping] Calcium release-activated calcium channel protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		89 aa 9.2 kDa	Yes	0
ORAI1-201 ENSP00000480616 ENST00000616379	Q96D31 [Direct mapping] Calcium release-activated calcium channel protein 1 A0A024RBT3 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0002115 [store-operated calcium entry] GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005776 [autophagosome] GO:0005887 [integral component of plasma membrane] GO:0007596 [blood coagulation] GO:0015279 [store-operated calcium channel activity] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0031410 [cytoplasmic vesicle] GO:0042802 [identical protein binding] GO:0043234 [protein complex] GO:0051924 [regulation of calcium ion transport] GO:0051928 [positive regulation of calcium ion transport] GO:0061180 [mammary gland epithelium development] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] Show all	301 aa 32.7 kDa	No	3