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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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GPIHBP1
  • premium

    TISSUE

  • CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1

Protein class

Disease related genes, Predicted secreted proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA066302

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Majority cases of renal cancer and two cases of endometrial cancer displayed weak to moderate cytoplasmic staining. Rest of cancer tissues were mostly negative.

GENE INFORMATION

Gene name

GPIHBP1 (HGNC Symbol)

Synonyms

GPI-HBP1, LOC338328

Description

Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a capillary endothelial cell protein that facilitates the lipolytic processing of triglyceride-rich lipoproteins. The encoded protein is a glycosylphosphatidylinositol-anchored protein that is a member of the lymphocyte antigen 6 (Ly6) family. This protein plays a major role in transporting lipoprotein lipase (LPL) from the subendothelial spaces to the capillary lumen. Mutations in this gene are the cause of hyperlipoproteinemia, type 1D. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Chromosome

8

Cytoband

q24.3

Chromosome location (bp)

143213193 - 143217170

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000277494 (version 83.38)

Entrez gene

338328

UniProt

Q8IV16 (UniProt - Evidence at protein level)

neXtProt

NX_Q8IV16

Antibodypedia

GPIHBP1 antibodies

PROTEIN BROWSER

GPIHBP1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GPIHBP1-001
ENSP00000480053
ENST00000622500
Q8IV16 [Direct mapping]
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1
Show all
   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Show all
GO:0005622 [intracellular]
GO:0006869 [lipid transport]
GO:0006886 [intracellular protein transport]
GO:0008035 [high-density lipoprotein particle binding]
GO:0008289 [lipid binding]
GO:0008320 [protein transmembrane transporter activity]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0017038 [protein import]
GO:0031362 [anchored component of external side of plasma membrane]
GO:0034364 [high-density lipoprotein particle]
GO:0034394 [protein localization to cell surface]
GO:0035473 [lipase binding]
GO:0035478 [chylomicron binding]
GO:0042632 [cholesterol homeostasis]
GO:0045056 [transcytosis]
GO:0046658 [anchored component of plasma membrane]
GO:0050821 [protein stabilization]
GO:0051006 [positive regulation of lipoprotein lipase activity]
GO:0070328 [triglyceride homeostasis]
GO:0071503 [response to heparin]
GO:0071806 [protein transmembrane transport]
GO:0071813 [lipoprotein particle binding]
GO:0090321 [positive regulation of chylomicron remnant clearance]
Show all
184 aa
19.8 kDa
Yes 0

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