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GPIHBP1

GENERAL INFORMATION

Gene name

 GPIHBP1

Gene description

 Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1

Protein class

 Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (adipose tissue, lung)
FANTOM5:Tissue enhanced (adipose tissue)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in adipocytes.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA066302
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Breast

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adipose tissue, lung)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adipose tissue)

GENE INFORMATION

Gene name

 GPIHBP1 (HGNC Symbol)

Synonyms

 GPI-HBP1, LOC338328

Description

 Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a capillary endothelial cell protein that facilitates the lipolytic processing of triglyceride-rich lipoproteins. The encoded protein is a glycosylphosphatidylinositol-anchored protein that is a member of the lymphocyte antigen 6 (Ly6) family. This protein plays a major role in transporting lipoprotein lipase (LPL) from the subendothelial spaces to the capillary lumen. Mutations in this gene are the cause of hyperlipoproteinemia, type 1D. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Chromosome

 8

Cytoband

 q24.3

Chromosome location (bp)

 143213193 - 143217170

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000277494 (version 83.38)

Entrez gene

 338328

UniProt

 Q8IV16 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IV16

Antibodypedia

 GPIHBP1 antibodies

PROTEIN BROWSER
GPIHBP1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GPIHBP1-001
ENSP00000480053
ENST00000622500
Q8IV16 [Direct mapping]
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1
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   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
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GO:0005622 [intracellular]
GO:0006869 [lipid transport]
GO:0006886 [intracellular protein transport]
GO:0008035 [high-density lipoprotein particle binding]
GO:0008289 [lipid binding]
GO:0008320 [protein transmembrane transporter activity]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0017038 [protein import]
GO:0031362 [anchored component of external side of plasma membrane]
GO:0034364 [high-density lipoprotein particle]
GO:0034394 [protein localization to cell surface]
GO:0035473 [lipase binding]
GO:0035478 [chylomicron binding]
GO:0042632 [cholesterol homeostasis]
GO:0045056 [transcytosis]
GO:0046658 [anchored component of plasma membrane]
GO:0050821 [protein stabilization]
GO:0051006 [positive regulation of lipoprotein lipase activity]
GO:0070328 [triglyceride homeostasis]
GO:0071503 [response to heparin]
GO:0071806 [protein transmembrane transport]
GO:0071813 [lipoprotein particle binding]
GO:0090321 [positive regulation of chylomicron remnant clearance]
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 184 aa
19.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.