Cell atlas - ATRIP - The Human Protein Atlas

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ATRIP

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ATRIP
Gene description	ATR interacting protein
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA047590
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA047590	HeLa	Nucleus
	HPA047590	RH-30	Nucleus
	HPA047590	U-2 OS	Nucleus

GENE INFORMATION
Gene name	ATRIP
Synonyms
Description	ATR interacting protein (EntrezGene)
Entrez gene summary	This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	48446710 - 48467645
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000282827 (version 83.38)
Entrez gene	84126
UniProt	Q8WXE1 (UniProt - Evidence at protein level), Q9NSU2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WXE1, NX_Q9NSU2
Antibodypedia	ATRIP antibodies

PROTEIN BROWSER

ATRIP-004	ATRIP-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATRIP-004 ENSP00000296443 ENST00000296443	Q9NSU2 [Direct mapping] Three-prime repair exonuclease 1 Q5TZT0 [Direct mapping] Three prime repair exonuclease 1; Three prime repair exonuclease 1, isoform CRA_g; Three-prime repair exonuclease 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0000738 [DNA catabolic process, exonucleolytic] GO:0003676 [nucleic acid binding] GO:0003697 [single-stranded DNA binding] GO:0004527 [exonuclease activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005730 [nucleolus] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006259 [DNA metabolic process] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006298 [mismatch repair] GO:0006310 [DNA recombination] GO:0008296 [3'-5'-exodeoxyribonuclease activity] GO:0008408 [3'-5' exonuclease activity] GO:0008853 [exodeoxyribonuclease III activity] GO:0016021 [integral component of membrane] GO:0032405 [MutLalpha complex binding] GO:0032407 [MutSalpha complex binding] GO:0032479 [regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] Show all	314 aa 33.2 kDa	No	1
ATRIP-201 ENSP00000349620 ENST00000357105	Q8WXE1 [Direct mapping] ATR-interacting protein Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0000077 [DNA damage checkpoint] GO:0000724 [double-strand break repair via homologous recombination] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006302 [double-strand break repair] GO:0036297 [interstrand cross-link repair] GO:0070530 [K63-linked polyubiquitin binding] Show all	664 aa 72.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.