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ATRIP

GENERAL INFORMATION

Gene name

 ATRIP

Gene description

 ATR interacting protein

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression. Additional cytoplasmic expression in a few tissues.

DATA RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. External characterization data supports antibody staining. Caution, Splice and/or transcript discrepancy exists.

Reliability score

 Approved based on 1 antibody.
HPA035437
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ATRIP

Synonyms

Description

 ATR interacting protein (EntrezGene)

Entrez gene summary

 This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 48446710 - 48467645

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000282827 (version 83.38)

Entrez gene

 84126

UniProt

 Q8WXE1 (UniProt - Evidence at protein level), Q9NSU2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WXE1, NX_Q9NSU2

Antibodypedia

 ATRIP antibodies

PROTEIN BROWSER
ATRIP-004
ATRIP-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATRIP-004
ENSP00000296443
ENST00000296443
Q9NSU2 [Direct mapping]
Three-prime repair exonuclease 1
Q5TZT0 [Direct mapping]
Three prime repair exonuclease 1; Three prime repair exonuclease 1, isoform CRA_g; Three-prime repair exonuclease 1
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0000738 [DNA catabolic process, exonucleolytic]
GO:0003676 [nucleic acid binding]
GO:0003697 [single-stranded DNA binding]
GO:0004527 [exonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005730 [nucleolus]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006259 [DNA metabolic process]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006298 [mismatch repair]
GO:0006310 [DNA recombination]
GO:0008296 [3'-5'-exodeoxyribonuclease activity]
GO:0008408 [3'-5' exonuclease activity]
GO:0008853 [exodeoxyribonuclease III activity]
GO:0016021 [integral component of membrane]
GO:0032405 [MutLalpha complex binding]
GO:0032407 [MutSalpha complex binding]
GO:0032479 [regulation of type I interferon production]
GO:0032481 [positive regulation of type I interferon production]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
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 314 aa
33.2 kDa 		No 1
ATRIP-201
ENSP00000349620
ENST00000357105
Q8WXE1 [Direct mapping]
ATR-interacting protein
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0036297 [interstrand cross-link repair]
GO:0070530 [K63-linked polyubiquitin binding]
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 664 aa
72.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.