Cell atlas - CFH - The Human Protein Atlas

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CFH

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	CFH
Gene description	Complement factor H
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enhanced (RT4, RH-30)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA038922
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RT4, RH-30) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA038922	A-431	Vesicles
	HPA038922	U-2 OS	No staining
	HPA038922	U-251 MG	Vesicles

GENE INFORMATION
Gene name	CFH (HGNC Symbol)
Synonyms	ARMD4, ARMS1, FHL1, HF, HF1, HF2, HUS
Description	Complement factor H (HGNC Symbol)
Entrez gene summary	This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Oct 2011]
Chromosome	1
Cytoband	q31.3
Chromosome location (bp)	196651878 - 196747504
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000000971 (version 83.38)
Entrez gene	3075
UniProt	P08603 (UniProt - Evidence at protein level)
neXtProt	NX_P08603
Antibodypedia	CFH antibodies

PROTEIN BROWSER

CFH-001	CFH-002	CFH-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CFH-001 ENSP00000356399 ENST00000367429	P08603 [Direct mapping] Complement factor H A0A024R962 [Target identity:100%; Query identity:100%] HCG40889, isoform CRA_b Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Mutational cancer driver genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006956 [complement activation] GO:0006957 [complement activation, alternative pathway] GO:0008201 [heparin binding] GO:0030449 [regulation of complement activation] GO:0043395 [heparan sulfate proteoglycan binding] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	1231 aa 139.1 kDa	Yes	0
CFH-002 ENSP00000352658 ENST00000359637	Q5TFM2 [Direct mapping] Complement factor H Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		385 aa 43.8 kDa	Yes	0
CFH-006 ENSP00000487250 ENST00000630130	A0A0D9SG88 [Direct mapping] Complement factor H Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		449 aa 51 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.