Tissue expression of CFH - Summary - The Human Protein Atlas

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CFH

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CFH
Gene description	Complement factor H
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (liver)
GTEx:	Expressed in all
FANTOM5:	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression

Distinct positivity in plasma and extracellular matrix.

DATA RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 5 antibodies. HPA038922 , HPA049176 , HPA053326 , CAB016385 , CAB016769
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (liver)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)

GENE INFORMATION
Gene name	CFH (HGNC Symbol)
Synonyms	ARMD4, ARMS1, FHL1, HF, HF1, HF2, HUS
Description	Complement factor H (HGNC Symbol)
Entrez gene summary	This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Oct 2011]
Chromosome	1
Cytoband	q31.3
Chromosome location (bp)	196651878 - 196747504
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000000971 (version 83.38)
Entrez gene	3075
UniProt	P08603 (UniProt - Evidence at protein level)
neXtProt	NX_P08603
Antibodypedia	CFH antibodies

PROTEIN BROWSER

CFH-001	CFH-002	CFH-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CFH-001 ENSP00000356399 ENST00000367429	P08603 [Direct mapping] Complement factor H A0A024R962 [Target identity:100%; Query identity:100%] HCG40889, isoform CRA_b Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Mutational cancer driver genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006956 [complement activation] GO:0006957 [complement activation, alternative pathway] GO:0008201 [heparin binding] GO:0030449 [regulation of complement activation] GO:0043395 [heparan sulfate proteoglycan binding] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	1231 aa 139.1 kDa	Yes	0
CFH-002 ENSP00000352658 ENST00000359637	Q5TFM2 [Direct mapping] Complement factor H Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		385 aa 43.8 kDa	Yes	0
CFH-006 ENSP00000487250 ENST00000630130	A0A0D9SG88 [Direct mapping] Complement factor H Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		449 aa 51 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.