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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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MPO
  • premium

    TISSUE

  • premium

    CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

Myeloperoxidase

Protein class

Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA021147
HPA061464
CAB000059

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues were negative.

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Thyroid cancers and few cases of urothelial cancers showed weak nuclear staining. Remaining cancer tissues were negative.

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer cells were negative.

GENE INFORMATION

Gene name

MPO

Synonyms

Description

Myeloperoxidase (HGNC Symbol)

Entrez gene summary

Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]

Chromosome

17

Cytoband

q22

Chromosome location (bp)

58269856 - 58280935

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000005381 (version 83.38)

Entrez gene

4353

UniProt

P05164 (UniProt - Evidence at protein level)

neXtProt

NX_P05164

Antibodypedia

MPO antibodies

PROTEIN BROWSER

MPO-001
MPO-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MPO-001
ENSP00000225275
ENST00000225275
P05164 [Direct mapping]
Myeloperoxidase Myeloperoxidase 89 kDa myeloperoxidase 84 kDa myeloperoxidase Myeloperoxidase light chain Myeloperoxidase heavy chain
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
Candidate cardiovascular disease genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001878 [response to yeast]
GO:0002149 [hypochlorous acid biosynthetic process]
GO:0002679 [respiratory burst involved in defense response]
GO:0003682 [chromatin binding]
GO:0004601 [peroxidase activity]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0006952 [defense response]
GO:0006979 [response to oxidative stress]
GO:0007568 [aging]
GO:0008201 [heparin binding]
GO:0009612 [response to mechanical stimulus]
GO:0019430 [removal of superoxide radicals]
GO:0020037 [heme binding]
GO:0030141 [secretory granule]
GO:0032094 [response to food]
GO:0032496 [response to lipopolysaccharide]
GO:0034374 [low-density lipoprotein particle remodeling]
GO:0042582 [azurophil granule]
GO:0042744 [hydrogen peroxide catabolic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0044130 [negative regulation of growth of symbiont in host]
GO:0046872 [metal ion binding]
GO:0050832 [defense response to fungus]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:1990268 [response to gold nanoparticle]
Show all
745 aa
83.9 kDa
Yes 0
MPO-005
ENSP00000464668
ENST00000577220
J3QSF7 [Direct mapping]
Myeloperoxidase
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004601 [peroxidase activity]
GO:0006952 [defense response]
GO:0006979 [response to oxidative stress]
GO:0020037 [heme binding]
GO:0055114 [oxidation-reduction process]
Show all
87 aa
9.9 kDa
No 0

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