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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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MPO
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

MPO

Gene description

Myeloperoxidase

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (bone marrow)
GTEx:Group enriched (spleen, lung)
FANTOM5:Tissue enhanced (heart muscle)

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in subsets of hematopoietic cells.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA021147 , HPA061464 , CAB000059
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (bone marrow)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (spleen, lung)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle)

GENE INFORMATION

Gene name

MPO

Synonyms

Description

Myeloperoxidase (HGNC Symbol)

Entrez gene summary

Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]

Chromosome

17

Cytoband

q22

Chromosome location (bp)

58269856 - 58280935

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000005381 (version 83.38)

Entrez gene

4353

UniProt

P05164 (UniProt - Evidence at protein level)

neXtProt

NX_P05164

Antibodypedia

MPO antibodies

PROTEIN BROWSER

MPO-001
MPO-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MPO-001
ENSP00000225275
ENST00000225275
P05164 [Direct mapping]
Myeloperoxidase Myeloperoxidase 89 kDa myeloperoxidase 84 kDa myeloperoxidase Myeloperoxidase light chain Myeloperoxidase heavy chain
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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
Candidate cardiovascular disease genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001878 [response to yeast]
GO:0002149 [hypochlorous acid biosynthetic process]
GO:0002679 [respiratory burst involved in defense response]
GO:0003682 [chromatin binding]
GO:0004601 [peroxidase activity]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0006952 [defense response]
GO:0006979 [response to oxidative stress]
GO:0007568 [aging]
GO:0008201 [heparin binding]
GO:0009612 [response to mechanical stimulus]
GO:0019430 [removal of superoxide radicals]
GO:0020037 [heme binding]
GO:0030141 [secretory granule]
GO:0032094 [response to food]
GO:0032496 [response to lipopolysaccharide]
GO:0034374 [low-density lipoprotein particle remodeling]
GO:0042582 [azurophil granule]
GO:0042744 [hydrogen peroxide catabolic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0044130 [negative regulation of growth of symbiont in host]
GO:0046872 [metal ion binding]
GO:0050832 [defense response to fungus]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:1990268 [response to gold nanoparticle]
Show all
745 aa
83.9 kDa
Yes 0
MPO-005
ENSP00000464668
ENST00000577220
J3QSF7 [Direct mapping]
Myeloperoxidase
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004601 [peroxidase activity]
GO:0006952 [defense response]
GO:0006979 [response to oxidative stress]
GO:0020037 [heme binding]
GO:0055114 [oxidation-reduction process]
Show all
87 aa
9.9 kDa
No 0

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