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PROM1

GENERAL INFORMATION

Gene name

 PROM1

Gene description

 Prominin 1

Protein class

 CD markers
Disease related genes
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cervix, uterine)
GTEx:Tissue enhanced (salivary gland)
FANTOM5:Tissue enhanced (salivary gland, retina)

Protein evidence

 Evidence at protein level

Protein expression

 Membrane and cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA004922 , HPA031053 , CAB011525
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cervix, uterine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (salivary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (salivary gland, retina)

GENE INFORMATION

Gene name

 PROM1 (HGNC Symbol)

Synonyms

 AC133, CD133, CORD12, MCDR2, PROML1, RP41, STGD4

Description

 Prominin 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Chromosome

 4

Cytoband

 p15.32

Chromosome location (bp)

 15963076 - 16084378

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000007062 (version 83.38)

Entrez gene

 8842

UniProt

 O43490 (UniProt - Evidence at protein level)

neXtProt

 NX_O43490

Antibodypedia

 PROM1 antibodies

PROTEIN BROWSER
PROM1-001
PROM1-003
PROM1-004
PROM1-009
PROM1-010
PROM1-011
PROM1-018
PROM1-201
PROM1-202
PROM1-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PROM1-001
ENSP00000426090
ENST00000505450
O43490 [Direct mapping]
Prominin-1
A0A0A0N0M1 [Target identity:100%; Query identity:100%]
CD133 isoform H
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001750 [photoreceptor outer segment]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0009986 [cell surface]
GO:0010842 [retina layer formation]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0031528 [microvillus membrane]
GO:0031982 [vesicle]
GO:0042622 [photoreceptor outer segment membrane]
GO:0042805 [actinin binding]
GO:0045296 [cadherin binding]
GO:0045494 [photoreceptor cell maintenance]
GO:0060042 [retina morphogenesis in camera-type eye]
GO:0060219 [camera-type eye photoreceptor cell differentiation]
GO:0070062 [extracellular exosome]
GO:0072112 [glomerular visceral epithelial cell differentiation]
GO:0072139 [glomerular parietal epithelial cell differentiation]
GO:2000768 [positive regulation of nephron tubule epithelial cell differentiation]
Show all
 856 aa
96.3 kDa 		Yes 5
PROM1-003
ENSP00000427346
ENST00000508167
O43490 [Direct mapping]
Prominin-1
A0A0A0N0M1 [Target identity:100%; Query identity:100%]
CD133 isoform H
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001750 [photoreceptor outer segment]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0009986 [cell surface]
GO:0010842 [retina layer formation]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0031528 [microvillus membrane]
GO:0031982 [vesicle]
GO:0042622 [photoreceptor outer segment membrane]
GO:0042805 [actinin binding]
GO:0045296 [cadherin binding]
GO:0045494 [photoreceptor cell maintenance]
GO:0060042 [retina morphogenesis in camera-type eye]
GO:0060219 [camera-type eye photoreceptor cell differentiation]
GO:0070062 [extracellular exosome]
GO:0072112 [glomerular visceral epithelial cell differentiation]
GO:0072139 [glomerular parietal epithelial cell differentiation]
GO:2000768 [positive regulation of nephron tubule epithelial cell differentiation]
Show all
 856 aa
96.3 kDa 		Yes 5
PROM1-004
ENSP00000426809
ENST00000510224
O43490 [Direct mapping]
Prominin-1
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001750 [photoreceptor outer segment]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005902 [microvillus]
GO:0005903 [brush border]
GO:0009986 [cell surface]
GO:0010842 [retina layer formation]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0031528 [microvillus membrane]
GO:0031982 [vesicle]
GO:0032420 [stereocilium]
GO:0042622 [photoreceptor outer segment membrane]
GO:0042805 [actinin binding]
GO:0042995 [cell projection]
GO:0045296 [cadherin binding]
GO:0045494 [photoreceptor cell maintenance]
GO:0060042 [retina morphogenesis in camera-type eye]
GO:0060219 [camera-type eye photoreceptor cell differentiation]
GO:0070062 [extracellular exosome]
GO:0072112 [glomerular visceral epithelial cell differentiation]
GO:0072139 [glomerular parietal epithelial cell differentiation]
GO:2000768 [positive regulation of nephron tubule epithelial cell differentiation]
Show all
 865 aa
97.2 kDa 		Yes 5
PROM1-009
ENSP00000422704
ENST00000508940
D6RBI0 [Direct mapping]
Prominin-1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 40 aa
4.1 kDa 		Yes 0
PROM1-010
ENSP00000425927
ENST00000508322
D6RIF3 [Direct mapping]
Prominin-1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
 58 aa
6.1 kDa 		Yes 0
PROM1-011
ENSP00000423793
ENST00000514967
D6RCC3 [Direct mapping]
Prominin-1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 14 aa
1.4 kDa 		No 0
PROM1-018
ENSP00000424738
ENST00000513946
H0Y9Q5 [Direct mapping]
Prominin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
 93 aa
10.5 kDa 		No 1
PROM1-201
ENSP00000415481
ENST00000447510
O43490 [Direct mapping]
Prominin-1
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001750 [photoreceptor outer segment]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0009986 [cell surface]
GO:0010842 [retina layer formation]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0031528 [microvillus membrane]
GO:0031982 [vesicle]
GO:0042622 [photoreceptor outer segment membrane]
GO:0042805 [actinin binding]
GO:0045296 [cadherin binding]
GO:0045494 [photoreceptor cell maintenance]
GO:0060042 [retina morphogenesis in camera-type eye]
GO:0060219 [camera-type eye photoreceptor cell differentiation]
GO:0070062 [extracellular exosome]
GO:0072112 [glomerular visceral epithelial cell differentiation]
GO:0072139 [glomerular parietal epithelial cell differentiation]
GO:2000768 [positive regulation of nephron tubule epithelial cell differentiation]
Show all
 865 aa
97.2 kDa 		Yes 5
PROM1-202
ENSP00000443620
ENST00000539194
O43490 [Direct mapping]
Prominin-1
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001750 [photoreceptor outer segment]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0009986 [cell surface]
GO:0010842 [retina layer formation]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0031528 [microvillus membrane]
GO:0031982 [vesicle]
GO:0042622 [photoreceptor outer segment membrane]
GO:0042805 [actinin binding]
GO:0045296 [cadherin binding]
GO:0045494 [photoreceptor cell maintenance]
GO:0060042 [retina morphogenesis in camera-type eye]
GO:0060219 [camera-type eye photoreceptor cell differentiation]
GO:0070062 [extracellular exosome]
GO:0072112 [glomerular visceral epithelial cell differentiation]
GO:0072139 [glomerular parietal epithelial cell differentiation]
GO:2000768 [positive regulation of nephron tubule epithelial cell differentiation]
Show all
 834 aa
93.7 kDa 		Yes 5
PROM1-203
ENSP00000438045
ENST00000540805
O43490 [Direct mapping]
Prominin-1
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001750 [photoreceptor outer segment]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0009986 [cell surface]
GO:0010842 [retina layer formation]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0031528 [microvillus membrane]
GO:0031982 [vesicle]
GO:0042622 [photoreceptor outer segment membrane]
GO:0042805 [actinin binding]
GO:0045296 [cadherin binding]
GO:0045494 [photoreceptor cell maintenance]
GO:0060042 [retina morphogenesis in camera-type eye]
GO:0060219 [camera-type eye photoreceptor cell differentiation]
GO:0070062 [extracellular exosome]
GO:0072112 [glomerular visceral epithelial cell differentiation]
GO:0072139 [glomerular parietal epithelial cell differentiation]
GO:2000768 [positive regulation of nephron tubule epithelial cell differentiation]
Show all
 842 aa
94.6 kDa 		Yes 5

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.