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PRSS3

CANCER ATLAS

Gene description

 Protease, serine, 3

Protein class

 Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Pancreatic cancer

STAINING SUMMARY
HPA062452
HPA063471

GENE INFORMATION

Gene name

 PRSS3 (HGNC Symbol)

Synonyms

 PRSS4, TRY3, TRY4

Description

 Protease, serine, 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]

Chromosome

 9

Cytoband

 p13.3

Chromosome location (bp)

 33750466 - 33799231

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000010438 (version 83.38)

Entrez gene

 5646

UniProt

 P35030 (UniProt - Evidence at protein level)

neXtProt

 NX_P35030

Antibodypedia

 PRSS3 antibodies

PROTEIN BROWSER
PRSS3-002
PRSS3-003
PRSS3-004
PRSS3-201
PRSS3-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRSS3-002
ENSP00000401249
ENST00000457896
B1AN99 [Direct mapping]
Trypsin-3
Show all
   SPOCTOPUS predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0006508 [proteolysis]
Show all
 178 aa
19.4 kDa 		No 0
PRSS3-003
ENSP00000354280
ENST00000361005
P35030 [Direct mapping]
Trypsin-3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006508 [proteolysis]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0007586 [digestion]
GO:0008236 [serine-type peptidase activity]
GO:0009235 [cobalamin metabolic process]
GO:0031638 [zymogen activation]
GO:0043542 [endothelial cell migration]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
Show all
 304 aa
32.5 kDa 		No 0
PRSS3-004
ENSP00000368715
ENST00000379405
P35030 [Direct mapping]
Trypsin-3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006508 [proteolysis]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0007586 [digestion]
GO:0008236 [serine-type peptidase activity]
GO:0009235 [cobalamin metabolic process]
GO:0031638 [zymogen activation]
GO:0043542 [endothelial cell migration]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
Show all
 247 aa
26.7 kDa 		Yes 0
PRSS3-201
ENSP00000340889
ENST00000342836
P35030 [Direct mapping]
Trypsin-3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   SPOCTOPUS predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006508 [proteolysis]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0007586 [digestion]
GO:0008236 [serine-type peptidase activity]
GO:0009235 [cobalamin metabolic process]
GO:0031638 [zymogen activation]
GO:0043542 [endothelial cell migration]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
Show all
 261 aa
28.4 kDa 		No 0
PRSS3-202
ENSP00000401828
ENST00000429677
P35030 [Direct mapping]
Trypsin-3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006508 [proteolysis]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0007586 [digestion]
GO:0008236 [serine-type peptidase activity]
GO:0009235 [cobalamin metabolic process]
GO:0031638 [zymogen activation]
GO:0043542 [endothelial cell migration]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
Show all
 240 aa
25.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.