Cell atlas - PRSS3 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PRSS3
Gene description	Protease, serine, 3
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles. In addition localized to the endoplasmic reticulum. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enriched (PC-3)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)
Additional location	In addition localized to the Endoplasmic reticulum (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA062452
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (PC-3) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles. In addition localized to the endoplasmic reticulum. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Vesicles (approved)

Additional location

Endoplasmic reticulum (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA062452	PC-3	Endoplasmic reticulum
HPA062452	SH-SY5Y	Vesicles
HPA062452	U-2 OS	Endoplasmic reticulum
HPA062452	U-2 OS	Vesicles

GENE INFORMATION
Gene name	PRSS3 (HGNC Symbol)
Synonyms	PRSS4, TRY3, TRY4
Description	Protease, serine, 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]
Chromosome	9
Cytoband	p13.3
Chromosome location (bp)	33750466 - 33799231
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000010438 (version 83.38)
Entrez gene	5646
UniProt	P35030 (UniProt - Evidence at protein level)
neXtProt	NX_P35030
Antibodypedia	PRSS3 antibodies

PROTEIN BROWSER

PRSS3-002	PRSS3-003	PRSS3-004	PRSS3-201	PRSS3-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRSS3-002 ENSP00000401249 ENST00000457896	B1AN99 [Direct mapping] Trypsin-3 Show all	SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	178 aa 19.4 kDa	No	0
PRSS3-003 ENSP00000354280 ENST00000361005	P35030 [Direct mapping] Trypsin-3 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0007586 [digestion] GO:0008236 [serine-type peptidase activity] GO:0009235 [cobalamin metabolic process] GO:0031638 [zymogen activation] GO:0043542 [endothelial cell migration] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] Show all	304 aa 32.5 kDa	No	0
PRSS3-004 ENSP00000368715 ENST00000379405	P35030 [Direct mapping] Trypsin-3 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0007586 [digestion] GO:0008236 [serine-type peptidase activity] GO:0009235 [cobalamin metabolic process] GO:0031638 [zymogen activation] GO:0043542 [endothelial cell migration] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] Show all	247 aa 26.7 kDa	Yes	0
PRSS3-201 ENSP00000340889 ENST00000342836	P35030 [Direct mapping] Trypsin-3 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0007586 [digestion] GO:0008236 [serine-type peptidase activity] GO:0009235 [cobalamin metabolic process] GO:0031638 [zymogen activation] GO:0043542 [endothelial cell migration] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] Show all	261 aa 28.4 kDa	No	0
PRSS3-202 ENSP00000401828 ENST00000429677	P35030 [Direct mapping] Trypsin-3 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0007586 [digestion] GO:0008236 [serine-type peptidase activity] GO:0009235 [cobalamin metabolic process] GO:0031638 [zymogen activation] GO:0043542 [endothelial cell migration] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] Show all	240 aa 25.9 kDa	No	0