We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
CD4
  • premium

    TISSUE

  • premium

    CELL

  • CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CD4

Gene description

CD4 molecule

Protein class

CD markers
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Intracellular,Membrane,Secreted

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (parathyroid gland)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in peripheral lymphocytes and subsets of cells in lymphoid tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

Supported based on 4 antibodies.
HPA004252 , HPA004472 , CAB000011 , CAB068180
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

CD4

Synonyms

Description

CD4 molecule (HGNC Symbol)

Entrez gene summary

This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]

Chromosome

12

Cytoband

p13.31

Chromosome location (bp)

6786858 - 6820808

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000010610 (version 83.38)

Entrez gene

920

UniProt

P01730 (UniProt - Evidence at protein level)

neXtProt

NX_P01730

Antibodypedia

CD4 antibodies

PROTEIN BROWSER

CD4-001
CD4-005
CD4-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD4-001
ENSP00000011653
ENST00000011653
P01730 [Direct mapping]
T-cell surface glycoprotein CD4
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0001816 [cytokine production]
GO:0001948 [glycoprotein binding]
GO:0002250 [adaptive immune response]
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005769 [early endosome]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006948 [induction by virus of host cell-cell fusion]
GO:0006955 [immune response]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007167 [enzyme linked receptor protein signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0008270 [zinc ion binding]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0015026 [coreceptor activity]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0019865 [immunoglobulin binding]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0030217 [T cell differentiation]
GO:0030260 [entry into host cell]
GO:0031295 [T cell costimulation]
GO:0032355 [response to estradiol]
GO:0032507 [maintenance of protein location in cell]
GO:0033280 [response to vitamin D]
GO:0035397 [helper T cell enhancement of adaptive immune response]
GO:0042101 [T cell receptor complex]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042110 [T cell activation]
GO:0042289 [MHC class II protein binding]
GO:0042803 [protein homodimerization activity]
GO:0045058 [T cell selection]
GO:0045086 [positive regulation of interleukin-2 biosynthetic process]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045234 [protein palmitoleylation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046718 [viral entry into host cell]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050850 [positive regulation of calcium-mediated signaling]
GO:0050852 [T cell receptor signaling pathway]
GO:0050863 [regulation of T cell activation]
GO:0050870 [positive regulation of T cell activation]
GO:1990782 [protein tyrosine kinase binding]
Show all
458 aa
51.1 kDa
Yes 1
CD4-005
ENSP00000445167
ENST00000541982
F5H480 [Direct mapping]
T-cell surface glycoprotein CD4
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007155 [cell adhesion]
GO:0016021 [integral component of membrane]
Show all
148 aa
16.5 kDa
No 0
CD4-007
ENSP00000440720
ENST00000539492
F5GYA9 [Direct mapping]
T-cell surface glycoprotein CD4
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
45 aa
4.8 kDa
Yes 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.