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PLAUR

CANCER ATLAS

Gene description

 Plasminogen activator, urokinase receptor

Protein class

 Cancer-related genes, CD markers, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA050843

GENE INFORMATION

Gene name

 PLAUR (HGNC Symbol)

Synonyms

 CD87, UPAR, URKR

Description

 Plasminogen activator, urokinase receptor (HGNC Symbol)

Entrez gene summary

 This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.31

Chromosome location (bp)

 43646095 - 43670547

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000011422 (version 83.38)

Entrez gene

 5329

UniProt

 Q03405 (UniProt - Evidence at protein level)

neXtProt

 NX_Q03405

Antibodypedia

 PLAUR antibodies

PROTEIN BROWSER
«
PLAUR-001
PLAUR-002
PLAUR-003
PLAUR-006
PLAUR-007
PLAUR-008
PLAUR-009
PLAUR-010
PLAUR-011
PLAUR-012
PLAUR-014
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLAUR-001
ENSP00000339328
ENST00000340093
Q03405 [Direct mapping]
Urokinase plasminogen activator surface receptor
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004872 [receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0006501 [C-terminal protein lipidation]
GO:0006928 [movement of cell or subcellular component]
GO:0006935 [chemotaxis]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0016021 [integral component of membrane]
GO:0016255 [attachment of GPI anchor to protein]
GO:0019898 [extrinsic component of membrane]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0030162 [regulation of proteolysis]
GO:0030377 [urokinase plasminogen activator receptor activity]
GO:0031225 [anchored component of membrane]
GO:0038195 [urokinase plasminogen activator signaling pathway]
GO:0042730 [fibrinolysis]
GO:0043066 [negative regulation of apoptotic process]
GO:0043388 [positive regulation of DNA binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0071438 [invadopodium membrane]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
GO:2001268 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 335 aa
37 kDa 		Yes 1
PLAUR-002
ENSP00000221264
ENST00000221264
Q03405 [Direct mapping]
Urokinase plasminogen activator surface receptor
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004872 [receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006501 [C-terminal protein lipidation]
GO:0006928 [movement of cell or subcellular component]
GO:0006935 [chemotaxis]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0016021 [integral component of membrane]
GO:0016255 [attachment of GPI anchor to protein]
GO:0019898 [extrinsic component of membrane]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0030162 [regulation of proteolysis]
GO:0030377 [urokinase plasminogen activator receptor activity]
GO:0031225 [anchored component of membrane]
GO:0038195 [urokinase plasminogen activator signaling pathway]
GO:0042730 [fibrinolysis]
GO:0043066 [negative regulation of apoptotic process]
GO:0043388 [positive regulation of DNA binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0071438 [invadopodium membrane]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
GO:2001268 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 290 aa
32 kDa 		Yes 1
PLAUR-003
ENSP00000342049
ENST00000339082
Q03405 [Direct mapping]
Urokinase plasminogen activator surface receptor
Show all
CD markers
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004872 [receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006501 [C-terminal protein lipidation]
GO:0006928 [movement of cell or subcellular component]
GO:0006935 [chemotaxis]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0016021 [integral component of membrane]
GO:0016255 [attachment of GPI anchor to protein]
GO:0019898 [extrinsic component of membrane]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0030162 [regulation of proteolysis]
GO:0030377 [urokinase plasminogen activator receptor activity]
GO:0031225 [anchored component of membrane]
GO:0038195 [urokinase plasminogen activator signaling pathway]
GO:0042730 [fibrinolysis]
GO:0043066 [negative regulation of apoptotic process]
GO:0043388 [positive regulation of DNA binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0071438 [invadopodium membrane]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
GO:2001268 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 281 aa
31.3 kDa 		Yes 0
PLAUR-006
ENSP00000470029
ENST00000599892
M0QYR6 [Direct mapping]
Urokinase plasminogen activator surface receptor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 226 aa
25.2 kDa 		No 0
PLAUR-007
ENSP00000472511
ENST00000593939
M0R2E9 [Direct mapping]
Urokinase plasminogen activator surface receptor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 152 aa
17.2 kDa 		No 0
PLAUR-008
ENSP00000468863
ENST00000599546
M0QX27 [Direct mapping]
Urokinase plasminogen activator surface receptor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 78 aa
8.9 kDa 		No 0
PLAUR-009
ENSP00000471241
ENST00000602141
M0R0H5 [Direct mapping]
Urokinase plasminogen activator surface receptor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 153 aa
17.1 kDa 		No 0
PLAUR-010
ENSP00000473055
ENST00000595038
M0R383 [Direct mapping]
Urokinase plasminogen activator surface receptor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 154 aa
16.8 kDa 		No 0
PLAUR-011
ENSP00000470050
ENST00000593447
M0QYS6 [Direct mapping]
Urokinase plasminogen activator surface receptor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 133 aa
14.9 kDa 		No 0
PLAUR-012
ENSP00000471881
ENST00000601723
M0R1I2 [Direct mapping]
Urokinase plasminogen activator surface receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
 286 aa
31.6 kDa 		Yes 1
PLAUR-014
ENSP00000471525
ENST00000593714
M0R0Y4 [Direct mapping]
Urokinase plasminogen activator surface receptor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 185 aa
20.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.