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This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]
CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001934 [positive regulation of protein phosphorylation] GO:0004872 [receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0006501 [C-terminal protein lipidation] GO:0006928 [movement of cell or subcellular component] GO:0006935 [chemotaxis] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] GO:0016021 [integral component of membrane] GO:0016255 [attachment of GPI anchor to protein] GO:0019898 [extrinsic component of membrane] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0030162 [regulation of proteolysis] GO:0030377 [urokinase plasminogen activator receptor activity] GO:0031225 [anchored component of membrane] GO:0038195 [urokinase plasminogen activator signaling pathway] GO:0042730 [fibrinolysis] GO:0043066 [negative regulation of apoptotic process] GO:0043388 [positive regulation of DNA binding] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway] GO:0070062 [extracellular exosome] GO:0071438 [invadopodium membrane] GO:0090200 [positive regulation of release of cytochrome c from mitochondria] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] GO:2001268 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001934 [positive regulation of protein phosphorylation] GO:0004872 [receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006501 [C-terminal protein lipidation] GO:0006928 [movement of cell or subcellular component] GO:0006935 [chemotaxis] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] GO:0016021 [integral component of membrane] GO:0016255 [attachment of GPI anchor to protein] GO:0019898 [extrinsic component of membrane] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0030162 [regulation of proteolysis] GO:0030377 [urokinase plasminogen activator receptor activity] GO:0031225 [anchored component of membrane] GO:0038195 [urokinase plasminogen activator signaling pathway] GO:0042730 [fibrinolysis] GO:0043066 [negative regulation of apoptotic process] GO:0043388 [positive regulation of DNA binding] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway] GO:0070062 [extracellular exosome] GO:0071438 [invadopodium membrane] GO:0090200 [positive regulation of release of cytochrome c from mitochondria] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] GO:2001268 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001934 [positive regulation of protein phosphorylation] GO:0004872 [receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006501 [C-terminal protein lipidation] GO:0006928 [movement of cell or subcellular component] GO:0006935 [chemotaxis] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] GO:0016021 [integral component of membrane] GO:0016255 [attachment of GPI anchor to protein] GO:0019898 [extrinsic component of membrane] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0030162 [regulation of proteolysis] GO:0030377 [urokinase plasminogen activator receptor activity] GO:0031225 [anchored component of membrane] GO:0038195 [urokinase plasminogen activator signaling pathway] GO:0042730 [fibrinolysis] GO:0043066 [negative regulation of apoptotic process] GO:0043388 [positive regulation of DNA binding] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway] GO:0070062 [extracellular exosome] GO:0071438 [invadopodium membrane] GO:0090200 [positive regulation of release of cytochrome c from mitochondria] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] GO:2001268 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
