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SARS

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GENERAL INFORMATION

Gene name

 SARS

Gene description

 Seryl-tRNA synthetase

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (validated)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA016939 , HPA064668
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol.

Main location

 Cytosol (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA016939 A-431 Cytosol
HPA016939 U-2 OS Cytosol
HPA016939 U-251 MG Cytosol
HPA064668 PC-3 Cytosol
HPA064668 SK-MEL-30 Cytosol
HPA064668 U-2 OS Cytosol

GENE INFORMATION

Gene name

 SARS (HGNC Symbol)

Synonyms

 SERS

Description

 Seryl-tRNA synthetase (HGNC Symbol)

Entrez gene summary

 This gene belongs to the class II amino-acyl tRNA family. The encoded enzyme catalyzes the transfer of L-serine to tRNA (Ser) and is related to bacterial and yeast counterparts. Multiple alternatively spliced transcript variants have been described but the biological validity of all variants is unknown. [provided by RefSeq, Jul 2010]

Chromosome

 1

Cytoband

 p13.3

Chromosome location (bp)

 109213918 - 109238169

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000031698 (version 83.38)

Entrez gene

 6301

UniProt

 P49591 (UniProt - Evidence at protein level)

neXtProt

 NX_P49591

Antibodypedia

 SARS antibodies

PROTEIN BROWSER
SARS-001
SARS-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SARS-001
ENSP00000234677
ENST00000234677
P49591 [Direct mapping]
Serine--tRNA ligase, cytoplasmic
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Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003723 [RNA binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004828 [serine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006434 [seryl-tRNA aminoacylation]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0070062 [extracellular exosome]
GO:0097056 [selenocysteinyl-tRNA(Sec) biosynthetic process]
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 514 aa
58.8 kDa 		No 0
SARS-004
ENSP00000358939
ENST00000369923
Q5T5C7 [Direct mapping]
Serine--tRNA ligase, cytoplasmic
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004828 [serine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006434 [seryl-tRNA aminoacylation]
Show all
 536 aa
61.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.