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RAB27B

GENERAL INFORMATION

Gene name

 RAB27B

Gene description

 RAB27B, member RAS oncogene family

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (stomach)
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression mainly in glandular cells of gastrointestinal tract, breast, salivary gland, prostate, cells in renal tubules and urothelial cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA019849 , CAB017712
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (stomach)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 RAB27B

Synonyms

Description

 RAB27B, member RAS oncogene family (HGNC Symbol)

Entrez gene summary

 Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking (Chen et al., 1997 [PubMed 9066979]).[supplied by OMIM, Nov 2010]

Chromosome

 18

Cytoband

 q21.2

Chromosome location (bp)

 54717860 - 54895516

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000041353 (version 83.38)

Entrez gene

 5874

UniProt

 O00194 (UniProt - Evidence at protein level)

neXtProt

 NX_O00194

Antibodypedia

 RAB27B antibodies

PROTEIN BROWSER
RAB27B-001
RAB27B-002
RAB27B-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAB27B-001
ENSP00000262094
ENST00000262094
O00194 [Direct mapping]
Ras-related protein Rab-27B
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005794 [Golgi apparatus]
GO:0005795 [Golgi stack]
GO:0006886 [intracellular protein transport]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0009306 [protein secretion]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0017157 [regulation of exocytosis]
GO:0019003 [GDP binding]
GO:0019904 [protein domain specific binding]
GO:0030140 [trans-Golgi network transport vesicle]
GO:0030141 [secretory granule]
GO:0030667 [secretory granule membrane]
GO:0031489 [myosin V binding]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
GO:0032585 [multivesicular body membrane]
GO:0042470 [melanosome]
GO:0042589 [zymogen granule membrane]
GO:0045921 [positive regulation of exocytosis]
GO:0070062 [extracellular exosome]
GO:0071985 [multivesicular body sorting pathway]
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 218 aa
24.6 kDa 		No 0
RAB27B-002
ENSP00000465009
ENST00000592334
K7EJ38 [Direct mapping]
Ras-related protein Rab-27B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005794 [Golgi apparatus]
GO:0006886 [intracellular protein transport]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0009306 [protein secretion]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0030141 [secretory granule]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
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 131 aa
15.1 kDa 		No 0
RAB27B-004
ENSP00000468542
ENST00000586570
K7ES41 [Direct mapping]
Ras-related protein Rab-27B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005794 [Golgi apparatus]
GO:0006886 [intracellular protein transport]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0007264 [small GTPase mediated signal transduction]
GO:0009306 [protein secretion]
GO:0015031 [protein transport]
GO:0030141 [secretory granule]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
Show all
 87 aa
9.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.