Expression of ARHGEF5 in cancer - Summary

CANCER ATLAS

Gene description

Rho guanine nucleotide exchange factor (GEF) 5

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA020980	HPA029504	HPA044188	HPA045619	HPA045699

GENE INFORMATION
Gene name	ARHGEF5 (HGNC Symbol)
Synonyms	GEF5, P60, TIM, TIM1
Description	Rho guanine nucleotide exchange factor (GEF) 5 (HGNC Symbol)
Entrez gene summary	Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q35
Chromosome location (bp)	144355288 - 144380632
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000050327 (version 83.38)
Entrez gene	7984
UniProt	Q12774 (UniProt - Evidence at protein level)
neXtProt	NX_Q12774
Antibodypedia	ARHGEF5 antibodies

PROTEIN BROWSER

ARHGEF5-001	ARHGEF5-002	ARHGEF5-004	ARHGEF5-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARHGEF5-001 ENSP00000056217 ENST00000056217	Q12774 [Direct mapping] Rho guanine nucleotide exchange factor 5 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002408 [myeloid dendritic cell chemotaxis] GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0030036 [actin cytoskeleton organization] GO:0032956 [regulation of actin cytoskeleton organization] GO:0035023 [regulation of Rho protein signal transduction] GO:0035556 [intracellular signal transduction] GO:0043087 [regulation of GTPase activity] GO:0043507 [positive regulation of JUN kinase activity] GO:0043547 [positive regulation of GTPase activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051493 [regulation of cytoskeleton organization] GO:0051496 [positive regulation of stress fiber assembly] GO:0071803 [positive regulation of podosome assembly] GO:0071944 [cell periphery] GO:1904591 [positive regulation of protein import] Show all	1597 aa 176.8 kDa	No	0
ARHGEF5-002 ENSP00000418745 ENST00000474817	H0Y895 [Direct mapping] Rho guanine nucleotide exchange factor 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0035023 [regulation of Rho protein signal transduction] GO:0035556 [intracellular signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	797 aa 89.1 kDa	No	0
ARHGEF5-004 ENSP00000417979 ENST00000498580	C9J591 [Direct mapping] Rho guanine nucleotide exchange factor 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		181 aa 20.2 kDa	No	0
ARHGEF5-005 ENSP00000418227 ENST00000471847	Q12774 [Direct mapping] Rho guanine nucleotide exchange factor 5 A0A090N7S2 [Target identity:100%; Query identity:100%] Rho guanine nucleotide exchange factor (GEF) 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0032956 [regulation of actin cytoskeleton organization] GO:0035023 [regulation of Rho protein signal transduction] GO:0035556 [intracellular signal transduction] GO:0043087 [regulation of GTPase activity] GO:0043507 [positive regulation of JUN kinase activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051493 [regulation of cytoskeleton organization] GO:0051496 [positive regulation of stress fiber assembly] GO:0071944 [cell periphery] GO:1904591 [positive regulation of protein import] Show all	519 aa 60.1 kDa	No	0