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ARHGEF5

GENERAL INFORMATION

Gene name

 ARHGEF5

Gene description

 Rho guanine nucleotide exchange factor (GEF) 5

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 5 antibodies.
HPA020980 , HPA029504 , HPA044188 , HPA045619 , HPA045699
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 ARHGEF5 (HGNC Symbol)

Synonyms

 GEF5, P60, TIM, TIM1

Description

 Rho guanine nucleotide exchange factor (GEF) 5 (HGNC Symbol)

Entrez gene summary

 Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q35

Chromosome location (bp)

 144355288 - 144380632

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000050327 (version 83.38)

Entrez gene

 7984

UniProt

 Q12774 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12774

Antibodypedia

 ARHGEF5 antibodies

PROTEIN BROWSER
ARHGEF5-001
ARHGEF5-002
ARHGEF5-004
ARHGEF5-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGEF5-001
ENSP00000056217
ENST00000056217
Q12774 [Direct mapping]
Rho guanine nucleotide exchange factor 5
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002408 [myeloid dendritic cell chemotaxis]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0030036 [actin cytoskeleton organization]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043087 [regulation of GTPase activity]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051493 [regulation of cytoskeleton organization]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0071803 [positive regulation of podosome assembly]
GO:0071944 [cell periphery]
GO:1904591 [positive regulation of protein import]
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 1597 aa
176.8 kDa 		No 0
ARHGEF5-002
ENSP00000418745
ENST00000474817
H0Y895 [Direct mapping]
Rho guanine nucleotide exchange factor 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
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 797 aa
89.1 kDa 		No 0
ARHGEF5-004
ENSP00000417979
ENST00000498580
C9J591 [Direct mapping]
Rho guanine nucleotide exchange factor 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 181 aa
20.2 kDa 		No 0
ARHGEF5-005
ENSP00000418227
ENST00000471847
Q12774 [Direct mapping]
Rho guanine nucleotide exchange factor 5
A0A090N7S2 [Target identity:100%; Query identity:100%]
Rho guanine nucleotide exchange factor (GEF) 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043087 [regulation of GTPase activity]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051493 [regulation of cytoskeleton organization]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0071944 [cell periphery]
GO:1904591 [positive regulation of protein import]
Show all
 519 aa
60.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.