Expression of CS in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Citrate synthase

Protein class

Citric acid cycle related proteins, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA038460	HPA038461	CAB075750	CAB075751	CAB075752	CAB075753	CAB075754

GENE INFORMATION
Gene name	CS
Synonyms
Description	Citrate synthase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a Krebs tricarboxylic acid cycle enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl coenzyme A. The enzyme is found in nearly all cells capable of oxidative metablism. This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q13.3
Chromosome location (bp)	56271699 - 56300392
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000062485 (version 83.38)
Entrez gene	1431
UniProt	O75390 (UniProt - Evidence at protein level)
neXtProt	NX_O75390
Antibodypedia	CS antibodies

PROTEIN BROWSER

CS-001	CS-002	CS-003	CS-009	CS-010	CS-011	CS-013	CS-018	CS-019	CS-027	CS-029	CS-030	CS-031	CS-032	CS-033	CS-034	CS-035	CS-036

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CS-001 ENSP00000342056 ENST00000351328	O75390 [Direct mapping] Citrate synthase, mitochondrial A0A024RB75 [Target identity:100%; Query identity:100%] Citrate synthase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Citric acid cycle related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004108 [citrate (Si)-synthase activity] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005975 [carbohydrate metabolic process] GO:0006099 [tricarboxylic acid cycle] GO:0006101 [citrate metabolic process] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] GO:0046912 [transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer] GO:0070062 [extracellular exosome] Show all	466 aa 51.7 kDa	No	1
CS-002 ENSP00000446779 ENST00000548567	A0A0C4DGI3 [Direct mapping] Citrate synthase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004108 [citrate (Si)-synthase activity] GO:0006099 [tricarboxylic acid cycle] GO:0006101 [citrate metabolic process] GO:0046912 [transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer] Show all	400 aa 44.7 kDa	No	1
CS-003 ENSP00000440543 ENST00000542324	B4DJV2 [Direct mapping] Citrate synthase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004108 [citrate (Si)-synthase activity] GO:0005739 [mitochondrion] GO:0006099 [tricarboxylic acid cycle] GO:0006101 [citrate metabolic process] GO:0046912 [transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer] Show all	453 aa 50.4 kDa	No	1
CS-009 ENSP00000449753 ENST00000551137	F8VX07 [Direct mapping] Citrate synthase, mitochondrial Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0046912 [transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer] Show all	114 aa 12.6 kDa	No	0
CS-010 ENSP00000448166 ENST00000551430	F8W642 [Direct mapping] Citrate synthase, mitochondrial Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0046912 [transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer] Show all	66 aa 7.4 kDa	No	0
CS-011 ENSP00000449427 ENST00000551473	F8VX68 [Direct mapping] Citrate synthase, mitochondrial Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0046912 [transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer] Show all	120 aa 13.3 kDa	No	0
CS-013 ENSP00000448172 ENST00000550655	F8W4S1 [Direct mapping] Citrate synthase, mitochondrial Show all	Phobius predicted secreted proteins Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0008152 [metabolic process] GO:0046912 [transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer] Show all	178 aa 19.4 kDa	No	0
CS-018 ENSP00000449025 ENST00000550734	F8VPA1 [Direct mapping] Citrate synthase, mitochondrial Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0046912 [transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer] Show all	144 aa 16.1 kDa	No	0
CS-019 ENSP00000449080 ENST00000548746	H0YIC4 [Direct mapping] Citrate synthase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006099 [tricarboxylic acid cycle] GO:0016021 [integral component of membrane] GO:0046912 [transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer] Show all	123 aa 14.1 kDa	No	1
CS-027 ENSP00000447948 ENST00000551968	F8VU34 [Direct mapping] Citrate synthase, mitochondrial Show all	Phobius predicted secreted proteins Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0046912 [transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer] Show all	142 aa 15.6 kDa	No	0
CS-029 ENSP00000447346 ENST00000550159	F8VZK9 [Direct mapping] Citrate synthase, mitochondrial Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0046912 [transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer] Show all	81 aa 9.1 kDa	No	0
CS-030 ENSP00000447442 ENST00000552688	F8W1S4 [Direct mapping] Citrate synthase, mitochondrial Show all	Phobius predicted secreted proteins Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0046912 [transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer] Show all	157 aa 17 kDa	No	0
CS-031 ENSP00000448667 ENST00000549221	F8VRI6 [Direct mapping] Citrate synthase, mitochondrial Show all	Phobius predicted secreted proteins Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0046912 [transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer] Show all	140 aa 15.5 kDa	No	0
CS-032 ENSP00000450403 ENST00000546930	F8VR34 [Direct mapping] Citrate synthase, mitochondrial Show all	Phobius predicted secreted proteins Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0046912 [transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer] Show all	146 aa 16 kDa	No	0
CS-033 ENSP00000447986 ENST00000548041	F8VTT8 [Direct mapping] Citrate synthase, mitochondrial Show all	Phobius predicted secreted proteins Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0008152 [metabolic process] GO:0046912 [transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer] Show all	149 aa 16.3 kDa	No	0
CS-034 ENSP00000450312 ENST00000551936	F8VPA1 [Direct mapping] Citrate synthase, mitochondrial Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0046912 [transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer] Show all	144 aa 16.1 kDa	No	0
CS-035 ENSP00000448409 ENST00000547298	F8VRP1 [Direct mapping] Citrate synthase, mitochondrial Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0046912 [transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer] Show all	118 aa 13.1 kDa	No	0
CS-036 ENSP00000450101 ENST00000551253	F8VPF9 [Direct mapping] Citrate synthase, mitochondrial Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0046912 [transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer] Show all	141 aa 15.8 kDa	No	0