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ATP2C2

GENERAL INFORMATION

Gene name

 ATP2C2

Gene description

 ATPase, Ca++ transporting, type 2C, member 2

Protein class

 Enzymes
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (rectum)
GTEx:Mixed
FANTOM5:Tissue enhanced (salivary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in several different tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA052262
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Smooth muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (rectum)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (salivary gland)

GENE INFORMATION

Gene name

 ATP2C2 (HGNC Symbol)

Synonyms

 KIAA0703, SPCA2

Description

 ATPase, Ca++ transporting, type 2C, member 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 16

Cytoband

 q24.1

Chromosome location (bp)

 84368527 - 84464187

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000064270 (version 83.38)

Entrez gene

 9914

UniProt

 O75185 (UniProt - Evidence at protein level)

neXtProt

 NX_O75185

Antibodypedia

 ATP2C2 antibodies

PROTEIN BROWSER
ATP2C2-001
ATP2C2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP2C2-001
ENSP00000262429
ENST00000262429
O75185 [Direct mapping]
Calcium-transporting ATPase type 2C member 2
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Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000166 [nucleotide binding]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005887 [integral component of plasma membrane]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0008152 [metabolic process]
GO:0015410 [manganese-transporting ATPase activity]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0071421 [manganese ion transmembrane transport]
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 946 aa
103.2 kDa 		No >9
ATP2C2-002
ENSP00000397925
ENST00000416219
A0A0A0MSP0 [Direct mapping]
Calcium-transporting ATPase
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006816 [calcium ion transport]
GO:0008152 [metabolic process]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0016021 [integral component of membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0061180 [mammary gland epithelium development]
GO:0070588 [calcium ion transmembrane transport]
GO:0072661 [protein targeting to plasma membrane]
GO:0090280 [positive regulation of calcium ion import]
Show all
 975 aa
106.2 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.