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Gene name

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Reliability

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Method

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Searches

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Expression

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Specificity

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Detectable

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ARFGEF1
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TISSUE ATLAS PRIMARY DATA
MOUSE BRAIN

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ARFGEF1

Gene description

ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA023399 , HPA023822
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Fallopian tube

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

ARFGEF1 (HGNC Symbol)

Synonyms

ARFGEP1, BIG1, DKFZP434L057, p200

Description

ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) (HGNC Symbol)

Entrez gene summary

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Aug 2011]

Chromosome

8

Cytoband

q13.2

Chromosome location (bp)

67173511 - 67343677

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000066777 (version 83.38)

Entrez gene

10565

UniProt

Q9Y6D6 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y6D6

Antibodypedia

ARFGEF1 antibodies

PROTEIN BROWSER

ARFGEF1-001
ARFGEF1-002
ARFGEF1-003
ARFGEF1-007
ARFGEF1-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ARFGEF1-001
ENSP00000262215
ENST00000262215
Q9Y6D6 [Direct mapping]
Brefeldin A-inhibited guanine nucleotide-exchange protein 1
A0A024R7X0 [Target identity:100%; Query identity:100%]
ADP-ribosylation factor guanine nucleotide-exchange factor 1(Brefeldin A-inhibited), isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005086 [ARF guanyl-nucleotide exchange factor activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0006887 [exocytosis]
GO:0007030 [Golgi organization]
GO:0010256 [endomembrane system organization]
GO:0015031 [protein transport]
GO:0016363 [nuclear matrix]
GO:0017022 [myosin binding]
GO:0030532 [small nuclear ribonucleoprotein complex]
GO:0030837 [negative regulation of actin filament polymerization]
GO:0031175 [neuron projection development]
GO:0032012 [regulation of ARF protein signal transduction]
GO:0034237 [protein kinase A regulatory subunit binding]
GO:0034260 [negative regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0090284 [positive regulation of protein glycosylation in Golgi]
GO:0090303 [positive regulation of wound healing]
GO:2000114 [regulation of establishment of cell polarity]
Show all
1849 aa
208.8 kDa
No 0
ARFGEF1-002
ENSP00000429002
ENST00000519436
E5RJN9 [Direct mapping]
Brefeldin A-inhibited guanine nucleotide-exchange protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005086 [ARF guanyl-nucleotide exchange factor activity]
GO:0005802 [trans-Golgi network]
GO:0043547 [positive regulation of GTPase activity]
Show all
118 aa
13.1 kDa
No 0
ARFGEF1-003
ENSP00000428429
ENST00000520381
E5RIF2 [Direct mapping]
Brefeldin A-inhibited guanine nucleotide-exchange protein 1
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005086 [ARF guanyl-nucleotide exchange factor activity]
GO:0005488 [binding]
GO:0005802 [trans-Golgi network]
GO:0032012 [regulation of ARF protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
1279 aa
145.5 kDa
No 0
ARFGEF1-007
ENSP00000430891
ENST00000518230
E5RHL7 [Direct mapping]
Brefeldin A-inhibited guanine nucleotide-exchange protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005086 [ARF guanyl-nucleotide exchange factor activity]
GO:0005488 [binding]
GO:0005802 [trans-Golgi network]
GO:0043547 [positive regulation of GTPase activity]
Show all
825 aa
93.7 kDa
No 0
ARFGEF1-010
ENSP00000429560
ENST00000518789
E5RHZ1 [Direct mapping]
Brefeldin A-inhibited guanine nucleotide-exchange protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005086 [ARF guanyl-nucleotide exchange factor activity]
GO:0005802 [trans-Golgi network]
GO:0043547 [positive regulation of GTPase activity]
Show all
192 aa
22.1 kDa
No 0

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