Cell atlas - ZFAT - The Human Protein Atlas

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ZFAT

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ZFAT
Gene description	Zinc finger and AT hook domain containing
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear bodies. In addition localized to the nucleoplasm.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear bodies (approved)
Additional location	In addition localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA063592
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear bodies. In addition localized to the nucleoplasm.

Main location

Nuclear bodies (approved)

Additional location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA063592	MCF7	Nucleoplasm
	HPA063592	MCF7	Nuclear bodies
	HPA063592	U-2 OS	Nuclear bodies

GENE INFORMATION
Gene name	ZFAT (HGNC Symbol)
Synonyms	KIAA1485, ZFAT1, ZNF406
Description	Zinc finger and AT hook domain containing (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]
Chromosome	8
Cytoband	q24.22
Chromosome location (bp)	134477788 - 134713049
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000066827 (version 83.38)
Entrez gene	57623
UniProt	Q9P243 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P243
Antibodypedia	ZFAT antibodies

PROTEIN BROWSER

ZFAT-001	ZFAT-004	ZFAT-005	ZFAT-006	ZFAT-007	ZFAT-009	ZFAT-011	ZFAT-015	ZFAT-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZFAT-001 ENSP00000367069 ENST00000377838	Q9P243 [Direct mapping] Zinc finger protein ZFAT Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007275 [multicellular organismal development] GO:0030097 [hemopoiesis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0060712 [spongiotrophoblast layer development] Show all	1243 aa 139 kDa	No	0
ZFAT-004 ENSP00000429091 ENST00000523399	Q9P243 [Direct mapping] Zinc finger protein ZFAT Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0007275 [multicellular organismal development] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] Show all	1181 aa 132.1 kDa	No	0
ZFAT-005 ENSP00000394501 ENST00000429442	F8W7M8 [Direct mapping] Zinc finger protein ZFAT Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	1156 aa 129.4 kDa	No	0
ZFAT-006 ENSP00000428483 ENST00000520214	Q9P243 [Direct mapping] Zinc finger protein ZFAT Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0007275 [multicellular organismal development] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] Show all	1231 aa 137.7 kDa	No	0
ZFAT-007 ENSP00000427831 ENST00000520727	Q9P243 [Direct mapping] Zinc finger protein ZFAT Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0007275 [multicellular organismal development] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] Show all	1231 aa 137.7 kDa	No	0
ZFAT-009 ENSP00000427879 ENST00000520356	E9PBN4 [Direct mapping] Zinc finger protein ZFAT Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	1145 aa 128.7 kDa	No	0
ZFAT-011 ENSP00000428192 ENST00000518191	E5RJT2 [Direct mapping] Zinc finger protein ZFAT Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046872 [metal ion binding] Show all	150 aa 16.4 kDa	No	0
ZFAT-015 ENSP00000429600 ENST00000521673	H0YBJ1 [Direct mapping] Zinc finger protein ZFAT Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		163 aa 17.9 kDa	No	0
ZFAT-016 ENSP00000429983 ENST00000522257	E5RGN2 [Direct mapping] Zinc finger protein ZFAT Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046872 [metal ion binding] Show all	196 aa 21.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.