Expression of TNFRSF1A in cancer - Summary

CANCER ATLAS

Gene description

Tumor necrosis factor receptor superfamily, member 1A

Protein class

Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Disease related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA004102	CAB010309

GENE INFORMATION
Gene name	TNFRSF1A (HGNC Symbol)
Synonyms	CD120a, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR60
Description	Tumor necrosis factor receptor superfamily, member 1A (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	6328757 - 6342114
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000067182 (version 83.38)
Entrez gene	7132
UniProt	P19438 (UniProt - Evidence at protein level)
neXtProt	NX_P19438
Antibodypedia	TNFRSF1A antibodies

PROTEIN BROWSER

TNFRSF1A-001	TNFRSF1A-002	TNFRSF1A-004	TNFRSF1A-010	TNFRSF1A-013	TNFRSF1A-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TNFRSF1A-001 ENSP00000162749 ENST00000162749	P19438 [Direct mapping] Tumor necrosis factor receptor superfamily member 1A Tumor necrosis factor receptor superfamily member 1A, membrane form Tumor necrosis factor-binding protein 1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005031 [tumor necrosis factor-activated receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005739 [mitochondrion] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006693 [prostaglandin metabolic process] GO:0006952 [defense response] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0007275 [multicellular organismal development] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0009986 [cell surface] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0032496 [response to lipopolysaccharide] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042511 [positive regulation of tyrosine phosphorylation of Stat1 protein] GO:0042742 [defense response to bacterium] GO:0042981 [regulation of apoptotic process] GO:0043120 [tumor necrosis factor binding] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043235 [receptor complex] GO:0045121 [membrane raft] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0050728 [negative regulation of inflammatory response] GO:0050729 [positive regulation of inflammatory response] GO:0071260 [cellular response to mechanical stimulus] GO:0071550 [death-inducing signaling complex assembly] GO:0090002 [establishment of protein localization to plasma membrane] GO:1903140 [regulation of establishment of endothelial barrier] GO:2000304 [positive regulation of ceramide biosynthetic process] Show all	455 aa 50.5 kDa	Yes	1
TNFRSF1A-002 ENSP00000438343 ENST00000540022	F5H061 [Direct mapping] Tumor necrosis factor receptor superfamily member 1A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] Show all	412 aa 45.7 kDa	Yes	1
TNFRSF1A-004 ENSP00000380389 ENST00000366159	P19438 [Direct mapping] Tumor necrosis factor receptor superfamily member 1A Tumor necrosis factor receptor superfamily member 1A, membrane form Tumor necrosis factor-binding protein 1 Show all	CD markers MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005031 [tumor necrosis factor-activated receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005739 [mitochondrion] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006693 [prostaglandin metabolic process] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007166 [cell surface receptor signaling pathway] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0007275 [multicellular organismal development] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0032496 [response to lipopolysaccharide] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042511 [positive regulation of tyrosine phosphorylation of Stat1 protein] GO:0042981 [regulation of apoptotic process] GO:0043120 [tumor necrosis factor binding] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043235 [receptor complex] GO:0045121 [membrane raft] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0050728 [negative regulation of inflammatory response] GO:0050729 [positive regulation of inflammatory response] GO:0071260 [cellular response to mechanical stimulus] GO:0071550 [death-inducing signaling complex assembly] GO:0090002 [establishment of protein localization to plasma membrane] GO:1903140 [regulation of establishment of endothelial barrier] GO:2000304 [positive regulation of ceramide biosynthetic process] Show all	218 aa 24.2 kDa	Yes	0
TNFRSF1A-010 ENSP00000442919 ENST00000536194	F5H6Z2 [Direct mapping] Tumor necrosis factor receptor superfamily member 1A Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	118 aa 12.8 kDa	Yes	0
TNFRSF1A-013 ENSP00000413224 ENST00000440083	F5H6V7 [Direct mapping] Tumor necrosis factor receptor superfamily member 1A Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005031 [tumor necrosis factor-activated receptor activity] GO:0005515 [protein binding] GO:0006693 [prostaglandin metabolic process] GO:0006954 [inflammatory response] GO:0016021 [integral component of membrane] GO:0033209 [tumor necrosis factor-mediated signaling pathway] Show all	254 aa 28.1 kDa	Yes	0
TNFRSF1A-014 ENSP00000442059 ENST00000539372	F5H8A6 [Direct mapping] Tumor necrosis factor receptor superfamily member 1A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005031 [tumor necrosis factor-activated receptor activity] GO:0005515 [protein binding] GO:0006693 [prostaglandin metabolic process] GO:0006954 [inflammatory response] GO:0016021 [integral component of membrane] GO:0033209 [tumor necrosis factor-mediated signaling pathway] Show all	298 aa 33.2 kDa	Yes	1