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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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TNFRSF1A
  • TISSUE

  • CELL

  • CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

TNFRSF1A

Gene description

Tumor necrosis factor receptor superfamily, member 1A

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
CD markers
Disease related genes
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in all tissues at variable levels.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 2 antibodies.
HPA004102 , CAB010309
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

TNFRSF1A (HGNC Symbol)

Synonyms

CD120a, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR60

Description

Tumor necrosis factor receptor superfamily, member 1A (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

p13.31

Chromosome location (bp)

6328757 - 6342114

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000067182 (version 83.38)

Entrez gene

7132

UniProt

P19438 (UniProt - Evidence at protein level)

neXtProt

NX_P19438

Antibodypedia

TNFRSF1A antibodies

PROTEIN BROWSER

TNFRSF1A-001
TNFRSF1A-002
TNFRSF1A-004
TNFRSF1A-010
TNFRSF1A-013
TNFRSF1A-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TNFRSF1A-001
ENSP00000162749
ENST00000162749
P19438 [Direct mapping]
Tumor necrosis factor receptor superfamily member 1A Tumor necrosis factor receptor superfamily member 1A, membrane form Tumor necrosis factor-binding protein 1
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005031 [tumor necrosis factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006693 [prostaglandin metabolic process]
GO:0006952 [defense response]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007275 [multicellular organismal development]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0009986 [cell surface]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016032 [viral process]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032496 [response to lipopolysaccharide]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042511 [positive regulation of tyrosine phosphorylation of Stat1 protein]
GO:0042742 [defense response to bacterium]
GO:0042981 [regulation of apoptotic process]
GO:0043120 [tumor necrosis factor binding]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043235 [receptor complex]
GO:0045121 [membrane raft]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050728 [negative regulation of inflammatory response]
GO:0050729 [positive regulation of inflammatory response]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071550 [death-inducing signaling complex assembly]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:1903140 [regulation of establishment of endothelial barrier]
GO:2000304 [positive regulation of ceramide biosynthetic process]
Show all
455 aa
50.5 kDa
Yes 1
TNFRSF1A-002
ENSP00000438343
ENST00000540022
F5H061 [Direct mapping]
Tumor necrosis factor receptor superfamily member 1A
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0016021 [integral component of membrane]
Show all
412 aa
45.7 kDa
Yes 1
TNFRSF1A-004
ENSP00000380389
ENST00000366159
P19438 [Direct mapping]
Tumor necrosis factor receptor superfamily member 1A Tumor necrosis factor receptor superfamily member 1A, membrane form Tumor necrosis factor-binding protein 1
Show all
CD markers
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005031 [tumor necrosis factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006693 [prostaglandin metabolic process]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007275 [multicellular organismal development]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016032 [viral process]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032496 [response to lipopolysaccharide]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042511 [positive regulation of tyrosine phosphorylation of Stat1 protein]
GO:0042981 [regulation of apoptotic process]
GO:0043120 [tumor necrosis factor binding]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043235 [receptor complex]
GO:0045121 [membrane raft]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050728 [negative regulation of inflammatory response]
GO:0050729 [positive regulation of inflammatory response]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071550 [death-inducing signaling complex assembly]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:1903140 [regulation of establishment of endothelial barrier]
GO:2000304 [positive regulation of ceramide biosynthetic process]
Show all
218 aa
24.2 kDa
Yes 0
TNFRSF1A-010
ENSP00000442919
ENST00000536194
F5H6Z2 [Direct mapping]
Tumor necrosis factor receptor superfamily member 1A
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
Show all
118 aa
12.8 kDa
Yes 0
TNFRSF1A-013
ENSP00000413224
ENST00000440083
F5H6V7 [Direct mapping]
Tumor necrosis factor receptor superfamily member 1A
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005031 [tumor necrosis factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0006693 [prostaglandin metabolic process]
GO:0006954 [inflammatory response]
GO:0016021 [integral component of membrane]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
Show all
254 aa
28.1 kDa
Yes 0
TNFRSF1A-014
ENSP00000442059
ENST00000539372
F5H8A6 [Direct mapping]
Tumor necrosis factor receptor superfamily member 1A
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005031 [tumor necrosis factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0006693 [prostaglandin metabolic process]
GO:0006954 [inflammatory response]
GO:0016021 [integral component of membrane]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
Show all
298 aa
33.2 kDa
Yes 1

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.