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TP53BP1

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GENERAL INFORMATION

Gene name

 TP53BP1

Gene description

 Tumor protein p53 binding protein 1

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nuclear bodies. In addition localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear bodies (validated)

Additional location

 In addition localized to the Nucleoplasm (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

Cell cycle dependency

 Cell cycle dependent expression determined by custom assay

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA008788 , HPA022133
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ASSAYS
RNA expression
Human cells
Custom data

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nuclear bodies. In addition localized to the nucleoplasm.

Main location

 Nuclear bodies (validated)

Additional location

 Nucleoplasm (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA022133 A-431 Nuclear bodies
HPA022133 U-2 OS Nucleoplasm Intensity Intensity
Nuclear bodies Intensity Intensity
HPA022133 U-251 MG Nucleoplasm Intensity
Nuclear bodies Intensity
HPA008788 A-431 Nuclear bodies
HPA008788 U-2 OS Nuclear bodies
HPA008788 U-251 MG Nuclear bodies

CUSTOM DATA

 

 

 
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Antibody

Cell line

Assay

Description
HPA022133 U-2 OS Image U-2 OS cells were treated with etoposide to induce DNA-damage and DNA-damage repair sites were marked with anti-53BP1 antibody. 53BP1 localizes at DNA-damage repair sites. HPA022133 and the anti-53BP1 antibody validate each other, as they show similar stainings for the same target protein.
 

 

 

 
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Antibody

Cell line

Assay

Description
HPA022133 U-2 OS Image Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. TP53BP1 is mostly expressed at the G1/S checkpoint.

CELL CYCLE

Summary

 Expression has cell cycle dependency according to custom assay

Intensity variation

 Nuclear bodies, Nucleoplasm

GENE INFORMATION

Gene name

 TP53BP1 (HGNC Symbol)

Synonyms

 53BP1, p202, TDRD30

Description

 Tumor protein p53 binding protein 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 15

Cytoband

 q15.3

Chromosome location (bp)

 43403061 - 43510728

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000067369 (version 83.38)

Entrez gene

 7158

UniProt

 Q12888 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12888

Antibodypedia

 TP53BP1 antibodies

PROTEIN BROWSER
TP53BP1-001
TP53BP1-002
TP53BP1-004
TP53BP1-005
TP53BP1-010
TP53BP1-013
TP53BP1-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TP53BP1-001
ENSP00000371475
ENST00000382044
Q12888 [Direct mapping]
Tumor suppressor p53-binding protein 1
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000781 [chromosome, telomeric region]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0002039 [p53 binding]
GO:0003684 [damaged DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006351 [transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0035064 [methylated histone binding]
GO:0042162 [telomeric DNA binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0071481 [cellular response to X-ray]
GO:1990391 [DNA repair complex]
Show all
 1977 aa
214.1 kDa 		No 0
TP53BP1-002
ENSP00000263801
ENST00000263801
Q12888 [Direct mapping]
Tumor suppressor p53-binding protein 1
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000777 [condensed chromosome kinetochore]
GO:0000781 [chromosome, telomeric region]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0002039 [p53 binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006351 [transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0035064 [methylated histone binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
Show all
 1972 aa
213.6 kDa 		No 0
TP53BP1-004
ENSP00000371470
ENST00000382039
A6NNK5 [Direct mapping]
Tumor suppressor p53-binding protein 1
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
Show all
 1927 aa
209 kDa 		No 0
TP53BP1-005
ENSP00000388028
ENST00000413546
C9JXV0 [Direct mapping]
Tumor suppressor p53-binding protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
Show all
 1033 aa
111.7 kDa 		No 0
TP53BP1-010
ENSP00000416212
ENST00000434595
H7C495 [Direct mapping]
Tumor suppressor p53-binding protein 1
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
 149 aa
16.4 kDa 		No 0
TP53BP1-013
ENSP00000471624
ENST00000467474
M0R142 [Direct mapping]
Tumor suppressor p53-binding protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
 144 aa
15.1 kDa 		No 0
TP53BP1-014
ENSP00000393497
ENST00000450115
Q12888 [Direct mapping]
Tumor suppressor p53-binding protein 1
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000777 [condensed chromosome kinetochore]
GO:0000781 [chromosome, telomeric region]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0002039 [p53 binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006351 [transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0035064 [methylated histone binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
Show all
 1975 aa
214 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.