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Gene name

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Reliability

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Searches

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Detectable

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TP53BP1
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    TISSUE

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    CELL

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

TP53BP1

Gene description

Tumor protein p53 binding protein 1

Protein class

Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA008788 , HPA022133 , CAB004083
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Nasopharynx

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin01020304050TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin051015202530RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina020406080100120140Tags Per Million

GENE INFORMATION

Gene name

TP53BP1 (HGNC Symbol)

Synonyms

53BP1, p202, TDRD30

Description

Tumor protein p53 binding protein 1 (HGNC Symbol)

Entrez gene summary

Chromosome

15

Cytoband

q15.3

Chromosome location (bp)

43403061 - 43510728

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000067369 (version 83.38)

Entrez gene

7158

UniProt

Q12888 (UniProt - Evidence at protein level)

neXtProt

NX_Q12888

Antibodypedia

TP53BP1 antibodies

PROTEIN BROWSER

TP53BP1-001
TP53BP1-002
TP53BP1-004
TP53BP1-005
TP53BP1-010
TP53BP1-013
TP53BP1-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TP53BP1-001
ENSP00000371475
ENST00000382044
Q12888 [Direct mapping]
Tumor suppressor p53-binding protein 1
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000781 [chromosome, telomeric region]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0002039 [p53 binding]
GO:0003684 [damaged DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006351 [transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0035064 [methylated histone binding]
GO:0042162 [telomeric DNA binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0071481 [cellular response to X-ray]
GO:1990391 [DNA repair complex]
Show all
1977 aa
214.1 kDa
No 0
TP53BP1-002
ENSP00000263801
ENST00000263801
Q12888 [Direct mapping]
Tumor suppressor p53-binding protein 1
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000777 [condensed chromosome kinetochore]
GO:0000781 [chromosome, telomeric region]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0002039 [p53 binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006351 [transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0035064 [methylated histone binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
Show all
1972 aa
213.6 kDa
No 0
TP53BP1-004
ENSP00000371470
ENST00000382039
A6NNK5 [Direct mapping]
Tumor suppressor p53-binding protein 1
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
Show all
1927 aa
209 kDa
No 0
TP53BP1-005
ENSP00000388028
ENST00000413546
C9JXV0 [Direct mapping]
Tumor suppressor p53-binding protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
Show all
1033 aa
111.7 kDa
No 0
TP53BP1-010
ENSP00000416212
ENST00000434595
H7C495 [Direct mapping]
Tumor suppressor p53-binding protein 1
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
149 aa
16.4 kDa
No 0
TP53BP1-013
ENSP00000471624
ENST00000467474
M0R142 [Direct mapping]
Tumor suppressor p53-binding protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
144 aa
15.1 kDa
No 0
TP53BP1-014
ENSP00000393497
ENST00000450115
Q12888 [Direct mapping]
Tumor suppressor p53-binding protein 1
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000777 [condensed chromosome kinetochore]
GO:0000781 [chromosome, telomeric region]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0002039 [p53 binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006351 [transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0035064 [methylated histone binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
Show all
1975 aa
214 kDa
No 0

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.