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A majority of malignant tissues displayed moderate to strong cytoplasmic immunoreactivity with a granular pattern. Several cases of squamous cell carcinomas, renal cancers and urothelial cancers were weakly stained were negative.
A majority of malignant melanomas, testicular seminomas, colorectal, breast, prostate, thyroid and liver cancers showed moderate to strong cytoplasmic staining with a granular pattern. Remaining malignant cells were in general weakly stained or negative.
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of isoleucine-tRNA synthetase exist, a cytoplasmic form and a mitochondrial form. This gene encodes the mitochondrial isoleucine-tRNA synthetase which belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Dec 2014]
Enzymes ENZYME proteins Ligase MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
