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IARS2

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GENERAL INFORMATION

Gene name

 IARS2

Gene description

 Isoleucyl-tRNA synthetase 2, mitochondrial

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the mitochondria.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Mitochondria (validated)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA024594 , HPA024596
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the mitochondria.

Main location

 Mitochondria (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA024594 A-431 Mitochondria
Cytosol
HPA024594 U-2 OS Mitochondria
HPA024594 U-251 MG Mitochondria
Cytosol
HPA024596 A-431 Mitochondria
HPA024596 U-2 OS Mitochondria
HPA024596 U-251 MG Mitochondria

GENE INFORMATION

Gene name

 IARS2 (HGNC Symbol)

Synonyms

 FLJ10326

Description

 Isoleucyl-tRNA synthetase 2, mitochondrial (HGNC Symbol)

Entrez gene summary

 Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of isoleucine-tRNA synthetase exist, a cytoplasmic form and a mitochondrial form. This gene encodes the mitochondrial isoleucine-tRNA synthetase which belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Dec 2014]

Chromosome

 1

Cytoband

 q41

Chromosome location (bp)

 220094102 - 220148041

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000067704 (version 83.38)

Entrez gene

 55699

UniProt

 Q9NSE4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NSE4

Antibodypedia

 IARS2 antibodies

PROTEIN BROWSER
IARS2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IARS2-001
ENSP00000355889
ENST00000366922
Q9NSE4 [Direct mapping]
Isoleucine--tRNA ligase, mitochondrial
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Enzymes
   ENZYME proteins
   Ligase
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002161 [aminoacyl-tRNA editing activity]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004822 [isoleucine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006428 [isoleucyl-tRNA aminoacylation]
GO:0006450 [regulation of translational fidelity]
GO:0010467 [gene expression]
GO:0032543 [mitochondrial translation]
Show all
 1012 aa
113.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.