Expression of VPS35 in cancer - Summary

CANCER ATLAS

Gene description

VPS35 retromer complex component

Protein class

Disease related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA040802

GENE INFORMATION
Gene name	VPS35 (HGNC Symbol)
Synonyms	FLJ10752, MEM3, PARK17
Description	VPS35 retromer complex component (HGNC Symbol)
Entrez gene summary	This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	q11.2
Chromosome location (bp)	46656132 - 46689518
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000069329 (version 83.38)
Entrez gene	55737
UniProt	Q96QK1 (UniProt - Evidence at protein level)
neXtProt	NX_Q96QK1
Antibodypedia	VPS35 antibodies

PROTEIN BROWSER

VPS35-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
VPS35-001 ENSP00000299138 ENST00000299138	Q96QK1 [Direct mapping] Vacuolar protein sorting-associated protein 35 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005765 [lysosomal membrane] GO:0005768 [endosome] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005829 [cytosol] GO:0006886 [intracellular protein transport] GO:0008565 [protein transporter activity] GO:0015031 [protein transport] GO:0030904 [retromer complex] GO:0030906 [retromer, cargo-selective complex] GO:0031647 [regulation of protein stability] GO:0042147 [retrograde transport, endosome to Golgi] GO:0045056 [transcytosis] GO:0070062 [extracellular exosome] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:0097422 [tubular endosome] GO:0097481 [neuronal postsynaptic density] GO:1902823 [negative regulation of late endosome to lysosome transport] GO:1990126 [retrograde transport, endosome to plasma membrane] Show all	796 aa 91.7 kDa	No	0