Fields »
ABOUT
HELP
BLOG
VPS35

GENERAL INFORMATION

Gene name

 VPS35

Gene description

 VPS35 retromer complex component

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA040802
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 VPS35 (HGNC Symbol)

Synonyms

 FLJ10752, MEM3, PARK17

Description

 VPS35 retromer complex component (HGNC Symbol)

Entrez gene summary

 This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q11.2

Chromosome location (bp)

 46656132 - 46689518

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000069329 (version 83.38)

Entrez gene

 55737

UniProt

 Q96QK1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96QK1

Antibodypedia

 VPS35 antibodies

PROTEIN BROWSER
VPS35-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VPS35-001
ENSP00000299138
ENST00000299138
Q96QK1 [Direct mapping]
Vacuolar protein sorting-associated protein 35
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0030904 [retromer complex]
GO:0030906 [retromer, cargo-selective complex]
GO:0031647 [regulation of protein stability]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0045056 [transcytosis]
GO:0070062 [extracellular exosome]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0097422 [tubular endosome]
GO:0097481 [neuronal postsynaptic density]
GO:1902823 [negative regulation of late endosome to lysosome transport]
GO:1990126 [retrograde transport, endosome to plasma membrane]
Show all
 796 aa
91.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.