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VPS35

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GENERAL INFORMATION

Gene name

 VPS35

Gene description

 VPS35 retromer complex component

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the endosome & lysosome.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Endosomes (supported), Lysosomes (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA040802
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ASSAYS
RNA expression
Human cells
Custom data

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the endosome & lysosome.

Main location

 Endosomes (supported), Lysosomes (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA040802 A-431 Endosomes
Lysosomes
HPA040802 U-2 OS Endosomes
Lysosomes
HPA040802 U-251 MG Endosomes
Lysosomes

CUSTOM DATA

 

 

 
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Antibody

Cell line

Assay

Description
HPA040802 U-2 OS Image VPS35 localizes to a subcompartment of endosomes, as it does not completely co-localize with the endosomal marker EEA1 on an endosome.
 

 

 

 
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Antibody

Cell line

Assay

Description
HPA040802 U-2 OS Image VPS35 localizes to retromers, as it co-localizes with the retromer marker VPS26A.
 

 

 

 
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Thumbnail

Antibody

Cell line

Assay

Description
HPA040802 U-2 OS Image VPS35 localizes to lysosomes, as it co-localizes with the lysosomal marker LAMP1/CD107a.

GENE INFORMATION

Gene name

 VPS35 (HGNC Symbol)

Synonyms

 FLJ10752, MEM3, PARK17

Description

 VPS35 retromer complex component (HGNC Symbol)

Entrez gene summary

 This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q11.2

Chromosome location (bp)

 46656132 - 46689518

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000069329 (version 83.38)

Entrez gene

 55737

UniProt

 Q96QK1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96QK1

Antibodypedia

 VPS35 antibodies

PROTEIN BROWSER
VPS35-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VPS35-001
ENSP00000299138
ENST00000299138
Q96QK1 [Direct mapping]
Vacuolar protein sorting-associated protein 35
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   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0030904 [retromer complex]
GO:0030906 [retromer, cargo-selective complex]
GO:0031647 [regulation of protein stability]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0045056 [transcytosis]
GO:0070062 [extracellular exosome]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0097422 [tubular endosome]
GO:0097481 [neuronal postsynaptic density]
GO:1902823 [negative regulation of late endosome to lysosome transport]
GO:1990126 [retrograde transport, endosome to plasma membrane]
Show all
 796 aa
91.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.