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Searches

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CDC42
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CDC42

Gene description

Cell division cycle 42

Protein class

Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

Intracellular

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
CAB004360
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

CDC42 (HGNC Symbol)

Synonyms

CDC42Hs, G25K

Description

Cell division cycle 42 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]

Chromosome

1

Cytoband

p36.12

Chromosome location (bp)

22052627 - 22092946

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000070831 (version 83.38)

Entrez gene

998

UniProt

P60953 (UniProt - Evidence at protein level)

neXtProt

NX_P60953

Antibodypedia

CDC42 antibodies

PROTEIN BROWSER

CDC42-001
CDC42-002
CDC42-004
CDC42-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDC42-001
ENSP00000341072
ENST00000344548
P60953 [Direct mapping]
Cell division control protein 42 homolog
A0A024RAE4 [Target identity:100%; Query identity:100%]
Cell division cycle 42 (GTP binding protein, 25kDa), isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007030 [Golgi organization]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016567 [protein ubiquitination]
GO:0019901 [protein kinase binding]
GO:0021762 [substantia nigra development]
GO:0030036 [actin cytoskeleton organization]
GO:0030175 [filopodium]
GO:0030225 [macrophage differentiation]
GO:0030307 [positive regulation of cell growth]
GO:0030496 [midbody]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0031295 [T cell costimulation]
GO:0031333 [negative regulation of protein complex assembly]
GO:0031996 [thioesterase binding]
GO:0032467 [positive regulation of cytokinesis]
GO:0034191 [apolipoprotein A-I receptor binding]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042692 [muscle cell differentiation]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051233 [spindle midzone]
GO:0051489 [regulation of filopodium assembly]
GO:0051683 [establishment of Golgi localization]
GO:0051988 [regulation of attachment of spindle microtubules to kinetochore]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0072384 [organelle transport along microtubule]
GO:0072686 [mitotic spindle]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
Show all
191 aa
21.3 kDa
No 0
CDC42-002
ENSP00000314458
ENST00000315554
P60953 [Direct mapping]
Cell division control protein 42 homolog
A0A024RAE6 [Target identity:100%; Query identity:100%]
Cell division cycle 42 (GTP binding protein, 25kDa), isoform CRA_c
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007030 [Golgi organization]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016567 [protein ubiquitination]
GO:0019901 [protein kinase binding]
GO:0021762 [substantia nigra development]
GO:0030036 [actin cytoskeleton organization]
GO:0030175 [filopodium]
GO:0030225 [macrophage differentiation]
GO:0030307 [positive regulation of cell growth]
GO:0030496 [midbody]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0031295 [T cell costimulation]
GO:0031333 [negative regulation of protein complex assembly]
GO:0031996 [thioesterase binding]
GO:0032467 [positive regulation of cytokinesis]
GO:0034191 [apolipoprotein A-I receptor binding]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042692 [muscle cell differentiation]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051233 [spindle midzone]
GO:0051489 [regulation of filopodium assembly]
GO:0051683 [establishment of Golgi localization]
GO:0051988 [regulation of attachment of spindle microtubules to kinetochore]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0072384 [organelle transport along microtubule]
GO:0072686 [mitotic spindle]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
Show all
191 aa
21.3 kDa
No 0
CDC42-004
ENSP00000398327
ENST00000411827
Q5JYX0 [Direct mapping]
Cell division control protein 42 homolog
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
136 aa
15.2 kDa
No 0
CDC42-201
ENSP00000383118
ENST00000400259
P60953 [Direct mapping]
Cell division control protein 42 homolog
A0A024RAE4 [Target identity:100%; Query identity:100%]
Cell division cycle 42 (GTP binding protein, 25kDa), isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000322 [storage vacuole]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002040 [sprouting angiogenesis]
GO:0003161 [cardiac conduction system development]
GO:0003334 [keratinocyte development]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0006897 [endocytosis]
GO:0007015 [actin filament organization]
GO:0007030 [Golgi organization]
GO:0007088 [regulation of mitotic nuclear division]
GO:0007097 [nuclear migration]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016567 [protein ubiquitination]
GO:0019901 [protein kinase binding]
GO:0021762 [substantia nigra development]
GO:0030036 [actin cytoskeleton organization]
GO:0030141 [secretory granule]
GO:0030175 [filopodium]
GO:0030225 [macrophage differentiation]
GO:0030307 [positive regulation of cell growth]
GO:0030496 [midbody]
GO:0030742 [GTP-dependent protein binding]
GO:0031069 [hair follicle morphogenesis]
GO:0031256 [leading edge membrane]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0031295 [T cell costimulation]
GO:0031333 [negative regulation of protein complex assembly]
GO:0031424 [keratinization]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0031647 [regulation of protein stability]
GO:0031996 [thioesterase binding]
GO:0032467 [positive regulation of cytokinesis]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034191 [apolipoprotein A-I receptor binding]
GO:0034332 [adherens junction organization]
GO:0034613 [cellular protein localization]
GO:0035088 [establishment or maintenance of apical/basal cell polarity]
GO:0035264 [multicellular organism growth]
GO:0036336 [dendritic cell migration]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042176 [regulation of protein catabolic process]
GO:0042692 [muscle cell differentiation]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043209 [myelin sheath]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043497 [regulation of protein heterodimerization activity]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045087 [innate immune response]
GO:0045177 [apical part of cell]
GO:0045740 [positive regulation of DNA replication]
GO:0045859 [regulation of protein kinase activity]
GO:0046330 [positive regulation of JNK cascade]
GO:0046847 [filopodium assembly]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048554 [positive regulation of metalloenzyme activity]
GO:0048664 [neuron fate determination]
GO:0048730 [epidermis morphogenesis]
GO:0051017 [actin filament bundle assembly]
GO:0051022 [Rho GDP-dissociation inhibitor binding]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051233 [spindle midzone]
GO:0051246 [regulation of protein metabolic process]
GO:0051489 [regulation of filopodium assembly]
GO:0051647 [nucleus localization]
GO:0051683 [establishment of Golgi localization]
GO:0051835 [positive regulation of synapse structural plasticity]
GO:0051988 [regulation of attachment of spindle microtubules to kinetochore]
GO:0060047 [heart contraction]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis]
GO:0060661 [submandibular salivary gland formation]
GO:0060684 [epithelial-mesenchymal cell signaling]
GO:0060789 [hair follicle placode formation]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0071338 [positive regulation of hair follicle cell proliferation]
GO:0071944 [cell periphery]
GO:0072384 [organelle transport along microtubule]
GO:0072686 [mitotic spindle]
GO:0090135 [actin filament branching]
GO:0090136 [epithelial cell-cell adhesion]
GO:0090316 [positive regulation of intracellular protein transport]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
Show all
191 aa
21.3 kDa
No 0

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