Fields »
ABOUT
HELP
BLOG
EPHA8

CANCER ATLAS

Gene description

 EPH receptor A8

Protein class

 Cancer-related genes, Enzymes, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Ovarian cancer

STAINING SUMMARY
HPA031433
CAB009660

GENE INFORMATION

Gene name

 EPHA8 (HGNC Symbol)

Synonyms

 EEK, Hek3

Description

 EPH receptor A8 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.12

Chromosome location (bp)

 22563564 - 22603594

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000070886 (version 83.38)

Entrez gene

 2046

UniProt

 P29322 (UniProt - Evidence at protein level)

neXtProt

 NX_P29322

Antibodypedia

 EPHA8 antibodies

PROTEIN BROWSER
EPHA8-001
EPHA8-002
EPHA8-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EPHA8-001
ENSP00000166244
ENST00000166244
P29322 [Direct mapping]
Ephrin type-A receptor 8
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005003 [ephrin receptor activity]
GO:0005004 [GPI-linked ephrin receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006929 [substrate-dependent cell migration]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007411 [axon guidance]
GO:0016021 [integral component of membrane]
GO:0016322 [neuron remodeling]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030155 [regulation of cell adhesion]
GO:0031175 [neuron projection development]
GO:0031901 [early endosome membrane]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0043005 [neuron projection]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0046777 [protein autophosphorylation]
GO:0048013 [ephrin receptor signaling pathway]
Show all
 1005 aa
111 kDa 		Yes 2
EPHA8-002
ENSP00000363775
ENST00000374644
P29322 [Direct mapping]
Ephrin type-A receptor 8
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0005003 [ephrin receptor activity]
GO:0005004 [GPI-linked ephrin receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006929 [substrate-dependent cell migration]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007411 [axon guidance]
GO:0016021 [integral component of membrane]
GO:0016322 [neuron remodeling]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030155 [regulation of cell adhesion]
GO:0031175 [neuron projection development]
GO:0031901 [early endosome membrane]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0043005 [neuron projection]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0046777 [protein autophosphorylation]
GO:0048013 [ephrin receptor signaling pathway]
Show all
 495 aa
53.9 kDa 		Yes 0
EPHA8-201
ENSP00000440274
ENST00000538803
P29322 [Direct mapping]
Ephrin type-A receptor 8
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0005003 [ephrin receptor activity]
GO:0005004 [GPI-linked ephrin receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006929 [substrate-dependent cell migration]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007411 [axon guidance]
GO:0016021 [integral component of membrane]
GO:0016322 [neuron remodeling]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030155 [regulation of cell adhesion]
GO:0031175 [neuron projection development]
GO:0031901 [early endosome membrane]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0043005 [neuron projection]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0046777 [protein autophosphorylation]
GO:0048013 [ephrin receptor signaling pathway]
Show all
 495 aa
53.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.