Tissue expression of EPHA8 - Summary - The Human Protein Atlas

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EPHA8

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	EPHA8
Gene description	EPH receptor A8
Protein class	Cancer-related genes Enzymes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (adrenal gland, spleen, testis)
GTEx:	Tissue enhanced (spleen, testis)
FANTOM5:	Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 2 antibodies. HPA031433 , CAB009660
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adrenal gland, spleen, testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen, testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen)

GENE INFORMATION
Gene name	EPHA8 (HGNC Symbol)
Synonyms	EEK, Hek3
Description	EPH receptor A8 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.12
Chromosome location (bp)	22563564 - 22603594
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000070886 (version 83.38)
Entrez gene	2046
UniProt	P29322 (UniProt - Evidence at protein level)
neXtProt	NX_P29322
Antibodypedia	EPHA8 antibodies

PROTEIN BROWSER

EPHA8-001	EPHA8-002	EPHA8-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EPHA8-001 ENSP00000166244 ENST00000166244	P29322 [Direct mapping] Ephrin type-A receptor 8 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005003 [ephrin receptor activity] GO:0005004 [GPI-linked ephrin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0006929 [substrate-dependent cell migration] GO:0007155 [cell adhesion] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007411 [axon guidance] GO:0016021 [integral component of membrane] GO:0016322 [neuron remodeling] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030155 [regulation of cell adhesion] GO:0031175 [neuron projection development] GO:0031901 [early endosome membrane] GO:0033628 [regulation of cell adhesion mediated by integrin] GO:0043005 [neuron projection] GO:0043410 [positive regulation of MAPK cascade] GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] GO:0046777 [protein autophosphorylation] GO:0048013 [ephrin receptor signaling pathway] Show all	1005 aa 111 kDa	Yes	2
EPHA8-002 ENSP00000363775 ENST00000374644	P29322 [Direct mapping] Ephrin type-A receptor 8 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0005003 [ephrin receptor activity] GO:0005004 [GPI-linked ephrin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0006929 [substrate-dependent cell migration] GO:0007155 [cell adhesion] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007411 [axon guidance] GO:0016021 [integral component of membrane] GO:0016322 [neuron remodeling] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030155 [regulation of cell adhesion] GO:0031175 [neuron projection development] GO:0031901 [early endosome membrane] GO:0033628 [regulation of cell adhesion mediated by integrin] GO:0043005 [neuron projection] GO:0043410 [positive regulation of MAPK cascade] GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] GO:0046777 [protein autophosphorylation] GO:0048013 [ephrin receptor signaling pathway] Show all	495 aa 53.9 kDa	Yes	0
EPHA8-201 ENSP00000440274 ENST00000538803	P29322 [Direct mapping] Ephrin type-A receptor 8 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0005003 [ephrin receptor activity] GO:0005004 [GPI-linked ephrin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0006929 [substrate-dependent cell migration] GO:0007155 [cell adhesion] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007411 [axon guidance] GO:0016021 [integral component of membrane] GO:0016322 [neuron remodeling] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030155 [regulation of cell adhesion] GO:0031175 [neuron projection development] GO:0031901 [early endosome membrane] GO:0033628 [regulation of cell adhesion mediated by integrin] GO:0043005 [neuron projection] GO:0043410 [positive regulation of MAPK cascade] GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] GO:0046777 [protein autophosphorylation] GO:0048013 [ephrin receptor signaling pathway] Show all	495 aa 53.9 kDa	Yes	0

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The Human Protein Atlas

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