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CRMP1

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GENERAL INFORMATION

Gene name

 CRMP1

Gene description

 Collapsin response mediator protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol.

RNA cell category

 Cell line enhanced (REH, SCLC-21H, RH-30, SH-SY5Y)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA035640
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (REH, SCLC-21H, RH-30, SH-SY5Y)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol.

Main location

 Cytosol (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA035640 U-2 OS Cytosol

GENE INFORMATION

Gene name

 CRMP1 (HGNC Symbol)

Synonyms

 DPYSL1, DRP-1

Description

 Collapsin response mediator protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 p16.2

Chromosome location (bp)

 5748084 - 5893058

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000072832 (version 83.38)

Entrez gene

 1400

UniProt

 Q14194 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14194

Antibodypedia

 CRMP1 antibodies

PROTEIN BROWSER
CRMP1-001
CRMP1-002
CRMP1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CRMP1-001
ENSP00000321606
ENST00000324989
Q14194 [Direct mapping]
Dihydropyrimidinase-related protein 1
X5DNI1 [Target identity:100%; Query identity:100%]
Collapsin response mediator protein 1 isoform A
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000226 [microtubule cytoskeleton organization]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0016787 [hydrolase activity]
GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds]
GO:0030425 [dendrite]
GO:0043025 [neuronal cell body]
GO:0048666 [neuron development]
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 686 aa
74.3 kDa 		No 0
CRMP1-002
ENSP00000425742
ENST00000512574
E9PD68 [Direct mapping]
Dihydropyrimidinase-related protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0005737 [cytoplasm]
GO:0007411 [axon guidance]
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds]
Show all
 570 aa
62 kDa 		No 0
CRMP1-003
ENSP00000380987
ENST00000397890
Q14194 [Direct mapping]
Dihydropyrimidinase-related protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0016787 [hydrolase activity]
GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds]
Show all
 572 aa
62.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.