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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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ACTB
  • premium

    TISSUE

  • CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

Actin, beta

Protein class

Disease related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA041264
HPA041271
CAB002621

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of cancer tissues showed moderate to strong membranous and/or cytoplasmic positivity.

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Colorectal, ovarian, endometrial, testicular, breast, urothelial, pancreatic and liver cancers displayed moderate to strong membranous staining. Malignant lymphomas exhibited moderate to strong cytoplasmic positivity. Remaining cancer tissues were weakly stained or negative.

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignant tissues displayed moderate to strong cytoplasmic and membranous immunoreactivity. Strongest staining was observed in malignant lymphomas, urothelial cancers and prostate cancers.

GENE INFORMATION

Gene name

ACTB

Synonyms

Description

Actin, beta (HGNC Symbol)

Entrez gene summary

This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

p22.1

Chromosome location (bp)

5527151 - 5563784

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000075624 (version 83.38)

Entrez gene

60

UniProt

P60709 (UniProt - Evidence at protein level)

neXtProt

NX_P60709

Antibodypedia

ACTB antibodies

PROTEIN BROWSER

ACTB-001
ACTB-008
ACTB-009
ACTB-010
ACTB-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACTB-001
ENSP00000349960
ENST00000331789
P60709 [Direct mapping]
Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed
Q1KLZ0 [Target identity:100%; Query identity:100%]
HCG15971, isoform CRA_a; PS1TP5-binding protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001895 [retina homeostasis]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006325 [chromatin organization]
GO:0006457 [protein folding]
GO:0006928 [movement of cell or subcellular component]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0016020 [membrane]
GO:0019894 [kinesin binding]
GO:0021762 [substantia nigra development]
GO:0030529 [ribonucleoprotein complex]
GO:0030957 [Tat protein binding]
GO:0031492 [nucleosomal DNA binding]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042802 [identical protein binding]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045216 [cell-cell junction organization]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0050998 [nitric-oxide synthase binding]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0070688 [MLL5-L complex]
GO:0072562 [blood microparticle]
GO:0097433 [dense body]
Show all
375 aa
41.7 kDa
No 0
ACTB-008
ENSP00000407473
ENST00000432588
E7EVS6 [Direct mapping]
Actin, cytoplasmic 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
164 aa
18 kDa
No 0
ACTB-009
ENSP00000393951
ENST00000443528
C9JZR7 [Direct mapping]
Actin, cytoplasmic 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
103 aa
11.4 kDa
No 0
ACTB-010
ENSP00000401032
ENST00000414620
C9JTX5 [Direct mapping]
Actin, cytoplasmic 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
80 aa
8.5 kDa
No 0
ACTB-012
ENSP00000399487
ENST00000417101
C9JUM1 [Direct mapping]
Actin, cytoplasmic 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
99 aa
11 kDa
No 0

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The Human Protein Atlas project is funded
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